Msb4p, a protein involved in Cdc42p-dependent organization of the actin cytoskeleton, is a Ypt/Rab-specific GAP

被引：35

作者：

Albert, S ^{[1
]}

Gallwitz, D ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, Dept Mol Genet, D-37070 Gottingen, Germany

来源：

BIOLOGICAL CHEMISTRY | 2000年 / 381卷 / 5-6期

关键词：

GTPase-activating protein; secretion; vesicular transport; yeast; Ypt/Rab GTPase;

D O I：

10.1515/BC.2000.059

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ypt/Rab proteins of the Has superfamily are regulators of protein transport in exo- and endocytosis. Like pas and Rho proteins, they have a slow intrinsic GTPase activity that can be accelerated by several orders of magnitude by GTPase-activating proteins (GAP). Here we describe a new member of a family of Ypt/Rab-specific GAPs, Msb4p/Gyp4p, that shares with other Gyp family members significant homology in the catalytic domain, recently identified in Gyp1p and Gyp7p. Purified Msb4p/Gyp4p acts primarily on Sec4p, Ypt6p and Ypt7p and might have a role in polarized secretion.

引用

页码：453 / 456

页数：4

共 15 条

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