A "hotspot" for autoimmune T cells in type 1 diabetes

被引:2
作者
Stadinski, Brian D. [1 ]
Obst, Reinhard [2 ]
Huseby, Eric S. [1 ]
机构
[1] Univ Massachusetts, Sch Med, Dept Pathol, AS9-1055 Sherman Ctr,368 Plantat St, Worcester, MA 01605 USA
[2] Univ Munich, Inst Immunol, Goethestr 31, D-80539 Munich, Germany
关键词
MAJOR HISTOCOMPATIBILITY COMPLEX; RECEPTOR RECOGNITION; MOLECULAR MIMICRY; PEPTIDE-MHC; ALLOREACTIVITY; ANTIGEN; SPECIFICITY; INTERFACES; PROTEIN; TCR;
D O I
10.1172/JCI88165
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The ability of a single T cell antigen receptor (TCR) to cross-react with multiple antigens allows the finite number of T cells within an organism to respond to the compendium of pathogen challenges faced during a lifetime. Effective immune surveillance, however, comes at a price. TCR cross-reactivity can allow molecular mimics to spuriously activate autoimmune T cells; it also underlies T cell rejection of organ transplants and drives graft-versus-host disease. In this issue of the JCI, Cole and colleagues provide insight into how an insulin-reactive T cell cross-reacts with pathogen-derived antigens by focusing on a limited portion of the peptides to provide a hotspot for binding. These findings dovetail with recent studies of alloreactive and autoimmune TCRs and suggest that the biochemical principles that govern conventional protein-protein interactions may allow the specificity and cross-reactivity profiles of T cells to be predicted.
引用
收藏
页码:2040 / 2042
页数:3
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