Improved Synthesis of Enantiopure 4-Hydroxy[2.2]paracyclophane

被引：46

作者：

Friedmann, Christian J. ^{[1
]}

Ay, Sefer ^{[1
]}

Braese, Stefan ^{[1
]}

机构：

[1] Karlsruhe Inst Technol, Inst Organ Chem, D-76131 Karlsruhe, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 13期

关键词：

EFFICIENT ROUTE; PSEUDO-ORTHO; MACRO RINGS; LIGANDS; PLANAR; DERIVATIVES; PARACYCLOPHANE; 2ND-GENERATION; RESOLUTION; CHIRALITY;

D O I：

10.1021/jo100468s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Hydroxy[2.2]paracyclophane is readily prepared via an improved synthetic protocol from unsubstituted[2.2]paracyclophane. The key step is a Dakin oxidation of 4-formyl[2.2]paracyclophane. This allows a rapid access to large quantities of the product and an easy synthesis of the enantiopure form.

引用

页码：4612 / 4614

页数：3

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