Autophagy: An overview and its roles in cancer and obesity

被引：58

作者：

Jacob, Joe Antony ^{[1
]}

Salmani, Jumah Masoud Mohammad ^{[1
]}

Jiang, Ziyu ^{[1
,2
]}

Feng, Liang ^{[3
]}

Song, Jie ^{[3
]}

Jia, Xiaobin ^{[3
]}

Chen, Baoan ^{[1
]}

机构：

[1] Southeast Univ, Sch Med, Zhongda Hosp, Dept Hematol & Oncol, Dingjiaqiao 87, Nanjing 210009, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Dept Oncol, Nanjing, Jiangsu, Peoples R China

[3] Jiangsu Prov Acad Chinese Med, Key Lab New Drug Delivery Syst Chinese Mat Med, Nanjing, Jiangsu, Peoples R China

来源：

CLINICA CHIMICA ACTA | 2017年 / 468卷

基金：

中国国家自然科学基金;

关键词：

Macroautophagy; Microautophagy; CMA; Cell survival; Cell killing; CHAPERONE-MEDIATED AUTOPHAGY; SMALL-MOLECULE; CELL-DEATH; IN-VITRO; MACROAUTOPHAGY; DEGRADATION; ACTIVATION; APOPTOSIS; MICROAUTOPHAGY; INHIBITION;

D O I：

10.1016/j.cca.2017.01.028

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Autophagy is a normal physiological process necessary for cellular homeostasis to maintain adequate levels of cellular components. It is essential to stabilize the source of energy during development and nutritional stress and plays the dual role of survival or cell killing in various diseases including cancer. The selectivity of the response to removal of selected organelles may vary according to the each type. Macroautophagy forms a double-membraned autophagosome around the organelle destined for processing. Microautophagy involves direct engulfment of the cellular components by lysosomal invagination. Chaperone mediated autophagy (CMA) is highly selective and is dependent on the chaperone hsc70 for its activity. The effects of all these types are implemented by autophagy related genes. In this review, the markers, activators, inhibitors biological effects and roles of the three classes of autophagy in cancer and obesity are discussed. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：85 / 89

页数：5

共 67 条

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[Anonymous], 2012, ISRN CELL BIOL

[2]

[Anonymous], 2015, EURASIP J WIRELESS C

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