Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity

被引：46

作者：

McEvoy, L. ^{[1
]}

Carr, D. F. ^{[1
]}

Pirmohamed, M. ^{[1
]}

机构：

[1] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool, Merseyside, England

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

基金：

英国医学研究理事会;

关键词：

pharmacogenomic; NSAID (non-steroidal anti-inflammatory drug); gastrointestinal toxicities; aspirin; adverse drug reaction; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ANTI-INFLAMMATORY DRUGS; CYTOCHROME P4502C9 GENOTYPE; NITRIC-OXIDE SYNTHASE; PEPTIC-ULCER DISEASE; DOSE ASPIRIN THERAPY; DOUBLE-BLIND; RISK-FACTORS; RHEUMATOID-ARTHRITIS; PHENOTYPE STANDARDIZATION;

D O I：

10.3389/fphar.2021.684162

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs which are widely used globally for the treatment of pain and inflammation, and in the case of aspirin, for secondary prevention of cardiovascular disease. Chronic non-steroidal anti-inflammatory drug use is associated with potentially serious upper gastrointestinal adverse drug reactions (ADRs) including peptic ulcer disease and gastrointestinal bleeding. A few clinical and genetic predisposing factors have been identified; however, genetic data are contradictory. Further research is needed to identify clinically relevant genetic and non-genetic markers predisposing to NSAID-induced peptic ulceration.

引用

页数：15

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