Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet

被引：170

作者：

Chen, Qiushui ^{[1
,2
]}

Utech, Stefanie ^{[2
]}

Chen, Dong ^{[2
]}

Prodanovic, Radivoje ^{[3
]}

Lin, Jin-Ming ^{[1
]}

Weitz, David A. ^{[2
]}

机构：

[1] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[2] MIT, Dept Phys, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02139 USA

[3] Univ Belgrade, Fac Chem, Studentskitrg 12, Belgrade, Serbia

来源：

LAB ON A CHIP | 2016年 / 16卷 / 08期

基金：

美国国家科学基金会; 美国国家卫生研究院; 中国国家自然科学基金;

关键词：

EXTRACELLULAR-MATRIX; STEM-CELLS; CHIPS; ENCAPSULATION; BIOMATERIALS; GENERATION; MICROGELS; HEPATOCYTES; CULTURE;

D O I：

10.1039/c6lc00231e

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop.

引用

页码：1346 / 1349

页数：4

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