Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet

被引：165
作者：
Chen, Qiushui [1 ,2 ]
Utech, Stefanie [2 ]
Chen, Dong [2 ]
Prodanovic, Radivoje [3 ]
Lin, Jin-Ming [1 ]
Weitz, David A. [2 ]
机构：
[1] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
[2] MIT, Dept Phys, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02139 USA
[3] Univ Belgrade, Fac Chem, Studentskitrg 12, Belgrade, Serbia
来源：
LAB ON A CHIP | 2016年 / 16卷 / 08期
基金：
中国国家自然科学基金; 美国国家科学基金会; 美国国家卫生研究院;
关键词：
EXTRACELLULAR-MATRIX; STEM-CELLS; CHIPS; ENCAPSULATION; BIOMATERIALS; GENERATION; MICROGELS; HEPATOCYTES; CULTURE;
D O I：
10.1039/c6lc00231e
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop.
引用
收藏
页码：1346 / 1349
页数：4
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