Talaromarins A-F: Six New Isocoumarins from Mangrove-Derived Fungus Talaromyces flavus TGGP35

被引：15

作者：

Cai, Jin ^{[1
,2
]}

Zhu, Xiao-Chen ^{[3
]}

Zeng, Wei-Nv ^{[1
,2
]}

Wang, Bin ^{[1
,2
]}

Luo, You-Ping ^{[1
,2
]}

Liu, Jing ^{[1
,2
]}

Chen, Min-Jing ^{[1
,2
]}

Li, Gao-Yu ^{[1
,2
]}

Huang, Guo-Lei ^{[1
,2
]}

Chen, Guang-Ying ^{[1
,2
]}

Xu, Jing ^{[3
]}

Zheng, Cai-Juan ^{[1
,2
]}

机构：

[1] Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Trop Med Resource Chem, Minist Educ, Haikou 571158, Hainan, Peoples R China

[2] Key Lab Trop Med Plant Chem Hainan Prov, Haikou 571158, Hainan, Peoples R China

[3] Hainan Univ, Sch Chem Engn & Technol, Key Lab Adv Mat Trop Isl Resources, Minist Educ, Haikou 570228, Hainan, Peoples R China

来源：

MARINE DRUGS | 2022年 / 20卷 / 06期

基金：

中国国家自然科学基金; 海南省自然科学基金;

关键词：

Talaromyces flavus; isocoumarins; antioxidant; antibacterial; alpha-glucosidase inhibitory activity; anti-phytopathogenic; SECONDARY METABOLITES; DERIVATIVES; BENZOFURANS;

D O I：

10.3390/md20060361

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new isocoumarin derivative talaromarins A-F (1-6), along with 17 known analogues (7-23), were isolated from the mangrove-derived fungus Talaromyces flavus (Eurotiales: Trichocomaceae) TGGP35. Their structures were identified by detailed IR, UV, 1D/2D NMR and HR-ESI-MS spectra. The absolute configurations of new compounds were determined by the modified Mosher's method and a comparison of their CD spectra with dihydroisocoumarins described in the literature. The antioxidant, antibacterial, anti-phytopathogenic and inhibitory activity against alpha-glucosidase of all the isolated compounds were tested. Compounds 6-11, 17-19 and 21-22 showed similar or better antioxidant activity than the IC50 values ranging from 0.009 to 0.27 mM, compared with the positive control trolox (IC50 = 0.29 mM). Compounds 10, 18, 21 and 23 exhibited strong inhibitory activities against alpha-glucosidase with IC50 values ranging from 0.10 to 0.62 mM, while the positive control acarbose had an IC50 value of 0.5 mM. All compounds showed no antibacterial or anti-phytopathogenic activity at the concentrations of 50 mu g/mL and 1 mg/mL, respectively. These results indicated that isocoumarins will be useful to developing antioxidants and as diabetes control agents.

引用

页数：13

共 40 条

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