Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour

被引:49
作者
Leppämäki, S
Partonen, T
Vakkuri, I
Lönnqvist, J
Partinen, M
Laudon, M
机构
[1] Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, FIN-00300 Helsinki, Finland
[2] Neurim Pharmaceut Ltd, Tel Aviv, Israel
[3] Univ Helsinki, Dept Neurol, Helsinki, Finland
[4] Haaga Neurol Res & Rehabil Ctr, Helsinki, Finland
[5] Univ Oulu, Dept Physiol, Oulu, Finland
[6] Univ Helsinki, Dept Psychiat, SF-00180 Helsinki, Finland
关键词
circadian; melatonin; mood; quality of life; sleep;
D O I
10.1016/S0924-977X(02)00175-X
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
This study aimed to explore the effects of melatonin on sleep, waking up and well being in subjects with varying degrees of seasonal or weather-associated changes in mood and behaviour. Fifty-eight healthy adults exhibiting subsyndromal seasonal affective disorder (s-SAD) and/or the negative or positive type of weather-associated syndrome (WAS) were randomised to either 2 mg of sustained-release melatonin or placebo tablets 1-2 h before a desired bedtime for 3 weeks. Outcome measures were changes from baseline in sleep quality, sleepiness after waking, atypical depressive symptoms and health-related quality of life by week three. Early morning salivary melatonin concentrations were measured at baseline and treatment cessation in all subjects. Melatonin administration significantly improved the quality of sleep (P=0.03) and vitality (P=0.02) in the subjects with s-SAD, but attenuated the improvement of atypical symptoms and physical parameters of quality of life compared to placebo in the subjects with WAS, positive type. (C) 2002 Elsevier Science B.V./ECNP All rights reserved.
引用
收藏
页码:137 / 145
页数:9
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