Reverse translation of major depressive disorder symptoms: A framework for the behavioural phenotyping of putative biomarkers

被引：7

作者：

Daniels, Stephen ^{[1
]}

Horman, Thomas ^{[1
]}

Lapointe, Thomas ^{[1
]}

Melanson, Brett ^{[1
]}

Storace, Alexandra ^{[1
]}

Kennedy, Sidney H. ^{[2
,4
]}

Frey, Benicio N. ^{[3
]}

Rizvi, Sakina J. ^{[2
,4
]}

Hassel, Stefanie ^{[5
]}

Mueller, Daniel J. ^{[6
]}

Parikh, Sagar, V ^{[7
]}

Lam, Raymond W. ^{[8
]}

Blier, Pierre ^{[9
]}

Farzan, Faranak ^{[10
]}

Giacobbe, Peter ^{[2
]}

Milev, Roumen ^{[11
]}

Placenza, Franca ^{[2
]}

Soares, Claudio N. ^{[11
]}

Turecki, Gustavo ^{[12
]}

Uher, Rudolf ^{[13
]}

Leri, Francesco ^{[1
]}

机构：

[1] Univ Guelph, Dept Psychol & Neurosci, Guelph, ON N1G 2W1, Canada

[2] Univ Toronto Hlth Network, Toronto, ON, Canada

[3] McMaster Univ, Hamilton, ON, Canada

[4] St Michaels Hosp, Toronto, ON, Canada

[5] Univ Calgary, Calgary, AB, Canada

[6] Ctr Addict & Mental Hlth, Toronto, ON, Canada

[7] Univ Michigan, Ann Arbor, MI 48109 USA

[8] Univ British Columbia, Vancouver, BC, Canada

[9] Royal Inst Mental Hlth Res, Ottawa, ON, Canada

[10] Simon Fraser Univ, Burnaby, BC, Canada

[11] Queens Univ, Kingston, ON, Canada

[12] McGill Univ, Montreal, PQ, Canada

[13] Dalhousie Univ, Halifax, NS, Canada

来源：

JOURNAL OF AFFECTIVE DISORDERS | 2020年 / 263卷

关键词：

Major depressive disorder; Montgomery-angstrom sberg depression rating scale; Hamilton rating scale for depression; Beck Depression inventory; Antidepressant drug treatment response; Reverse translation; CHRONIC MILD STRESS; FORCED SWIM TEST; ACUTE ANTIDEPRESSANT RESPONSE; LEARNED HELPLESSNESS MODEL; TRANSPORTER KNOCKOUT MICE; VENTRAL TEGMENTAL AREA; REPEATED SOCIAL DEFEAT; EYE-MOVEMENT SLEEP; ANIMAL-MODELS; RECEPTOR ANTAGONIST;

D O I：

10.1016/j.jad.2019.11.108

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Reverse translating putative biomarkers of depression from patients to animals is complex because Major Depressive Disorder (MDD) is a highly heterogenous condition. This review proposes an approach to reverse translation based on relating relevant bio-behavioural functions in laboratory rodents to MDD symptoms. Methods: This systematic review outlines symptom clusters assessed by psychometric tests of MDD and antidepressant treatment response including the Montgomery-Asberg Depression Rating Scale, the Hamilton Depression Rating Scale, and the Beck Depression Inventory. Symptoms were related to relevant behavioural assays in laboratory rodents. Results: The resulting battery of tests includes passive coping, anxiety-like behaviours, sleep, caloric intake, cognition, psychomotor functions, hedonic reactivity and aversive learning. These assays are discussed alongside relevant clinical symptoms of MDD, providing a framework through which reverse translation of a biomarker can be interpreted. Limitations: Certain aspects of MDD may not be quantified by tests in laboratory rodents, and their biological significance may not always be of clinical relevance. Conclusions: Using this reverse translation approach, it is possible to clarify the functional significance of a putative biomarker in rodents and hence translate its contribution to specific clinical symptoms, or clusters of symptoms.

引用

页码：353 / 366

页数：14

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