Magnetic nanobubbles with potential for targeted drug delivery and trimodal imaging in breast cancer: an in vitro study

被引：37

作者：

Song, Weixiang ^{[1
]}

Luo, Yindeng ^{[1
]}

Zhao, Yajing ^{[2
]}

Liu, Xinjie ^{[1
]}

Zhao, Jiannong ^{[1
]}

Luo, Jie ^{[2
]}

Zhang, Qunxia ^{[3
]}

Ran, Haitao ^{[3
]}

Wang, Zhigang ^{[3
]}

Guo, Dajing ^{[1
]}

机构：

[1] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China

[2] Chongqing Med Univ, Affiliated Hosp 1, Dept Ultrasound, 1 Youyi Rd, Chongqing 400016, Peoples R China

[3] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Dept Ultrasound, 74 Linjiang Rd, Chongqing 400010, Peoples R China

来源：

NANOMEDICINE | 2017年 / 12卷 / 09期

关键词：

magnetic resonance; nanobubble; PEGlyated PLGA; photoacoustic; target; ultrasound; SUPERPARAMAGNETIC IRON-OXIDE; ULTRASOUND CONTRAST AGENTS; LOADED MICROBUBBLES; HIFU ABLATION; NANOPARTICLES; THERAPY; TUMOR; MR; TRASTUZUMAB; DOXORUBICIN;

D O I：

10.2217/nnm-2017-0027

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The aim of this study was to improve tumor-targeted therapy for breast cancer by designing magnetic nanobubbles with the potential for targeted drug delivery and multimodal imaging. Materials & methods: Herceptin-decorated and ultrasmall superparamagnetic iron oxide (USPIO)/paclitaxel (PTX)-embedded nanobubbles (PTX-USPIO-HER-NBs) were manufactured by combining a modified double-emulsion evaporation process with carbodiimide technique. PTX-USPIOHER-NBs were examined for characterization, specific cell-targeting ability and multimodal imaging. Results: PTX-USPIO-HER-NBs exhibited excellent entrapment efficiency of Herceptin/PTX/USPIO and showed greater cytotoxic effects than other delivery platforms. Low-frequency ultrasound triggered accelerated PTX release. Moreover, the magnetic nanobubbles were able to enhance ultrasound, magnetic resonance and photoacoustics trimodal imaging. Conclusion: These results suggest that PTX-USPIO-HER-NBs have potential as a multimodal contrast agent and as a system for ultrasound-triggered drug release in breast cancer.

引用

页码：991 / 1009

页数：19

共 56 条

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