Multifunction in One Nanoparticle for Anticancer Therapy: Bowl-Shaped Au@PDA Yolk-Shell NPs

被引:18
作者
Ding, Xin [1 ,2 ]
Wang, Tianyu [3 ]
Bai, Shiwei [4 ]
Wan, Yunfeng [1 ,2 ]
Zhu, Shuai [1 ,2 ]
Li, Tao [1 ,2 ]
Peng, Na [1 ,2 ]
Qiu, Tao [3 ]
Liu, Yi [1 ,2 ,5 ,6 ]
机构
[1] Wuhan Univ Sci & Technol, Coll Chem & Chem Engn, Key Lab Coal Convers & New Carbon Mat Hubei Prov, Wuhan 430081, Peoples R China
[2] Wuhan Univ Sci & Technol, Coll Chem & Chem Engn, Inst Adv Technol & Nanomat, Wuhan 430081, Peoples R China
[3] Wuhan Univ, Dept Organ Transplantat, Renmin Hosp, Wuhan 430060, Peoples R China
[4] Northeast Normal Univ, Dept Chem, Changchun 130024, Peoples R China
[5] Tiangong Univ, Sch Chem, State Key Lab Separat Membrane & Membrane Proc, Tianjin 300387, Peoples R China
[6] Tiangong Univ, Sch Chem, Tianjin Key Lab Green Chem Technol & Proc Engn, Tianjin 300387, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
bowl-shaped nanoparticles; pH/NIR dual-responsive properties; photothermal therapy; chemotherapy; CT/PA imaging; PHOTOTHERMAL THERAPY; CANCER-IMMUNOTHERAPY; JANUS NANOPARTICLES; DRUG-DELIVERY; POLYDOPAMINE; RELEASE; CHEMOTHERAPY; DEGRADATION;
D O I
10.1021/acsami.2c07671
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Multifunctional nanoparticles (NPs) with simultaneous multimodal therapeutic and imaging capabilities are very necessary for biomedical applications. We successfully prepared bowl-shaped gold@ polydopamine yolk-shell NPs (bowl-shaped Au@PDA YNPs) by a novel and facile method. The unique bowl-like structure enables a drug loading rate of 92% (920 mu g mg(-1)). The bowl-shaped Au@PDA YNPs are biocompatible, have good photothermal conversion and strong nearinfrared (NIR) absorption, and can control drug release under pH/NIR dual response. Bowl-shaped Au@PDA YNPs can also be employed as contrast agents for computed tomography/photoacoustic imaging for dual-modal imaging-guided chemotherapy and photothermal therapy due to the presence of Au NPs.
引用
收藏
页码:27733 / 27742
页数:10
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