CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatin

被引：74

作者：

Ohlsson, Rolf ^{[1
]}

Bartkuhn, Marek ^{[2
]}

Renkawitz, Rainer ^{[2
]}

机构：

[1] Karolinska Inst, Inst Microbiol Tumor & Cellbiol, Stockholm, Sweden

[2] Univ Giessen, Inst Genet, D-35392 Giessen, Germany

来源：

CHROMOSOMA | 2010年 / 119卷 / 04期

关键词：

IMPRINTING CONTROL REGION; INSULATOR PROTEIN CTCF; BETA-GLOBIN LOCUS; ENHANCER-BLOCKING ACTIVITY; THYROID-HORMONE RECEPTOR; METHYLATION-FREE DOMAINS; RNA-POLYMERASE-II; BINDING-SITES; X-INACTIVATION; HUMAN GENOME;

D O I：

10.1007/s00412-010-0262-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

More than 10(9) base pairs of the genome in higher eucaryotes are positioned in the interphase nucleus such that gene activation, gene repression, remote gene regulation by enhancer elements, and reading as well as adjusting epigenetic marks are possible. One important structural and functional component of chromatin organization is the zinc finger factor CTCF. Two decades of research has advanced the understanding of the fundamental role that CTCF plays in regulating such a vast expanse of DNA.

引用

页码：351 / 360

页数：10

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