SYNTHESIS AND BIOLOGICAL ACTIVITY OF 4′-(5-AMINO-6-CHLORO-2-SUBSTITUTED-BENZOIMIDAZOL-1-YLMETHYL)]-BIPHENYL-2-CARBOXYLIC ACID AS ANTIHYPERTENSIVE AGENTS

被引：0
|
作者：
Sharma, M. C. [1 ]
Kohli, D. V. [1 ]
Sharma, Smita [2 ]
机构：
[1] Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Sagar 470003, MP, India
[2] Yadhunath Mahavidyalya, Dept Chem, Bhind 477001, MP, India
来源：
DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES | 2010年 / 5卷 / 03期
关键词：
5-Amino; angiotensin II; antihypertensive agents; II RECEPTOR ANTAGONISTS; CONVERTING ENZYME; ANGIOTENSIN; COUGH; AT1;
D O I：
暂无
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A series of 4'-(5-Amino-6-chloro-2-substituted-benzoimidazol-1-ylmethyl)]-biphenyl-2-carboxylic acid side chain in the 2 position have been synthesized from substituted compounds [1-14] compounds aromatic aldhyde, ayl, alkyl groups and tested for antihypertensive activity in induced hypertensive rats. All the compounds have been found to be less active than Losartan, Telmisartan their structures were assigned with elemental analysis, melting point and spectral analysis like (I)R, (1)H NMR, (13)C NMR and EI MS
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页码：605 / 621
页数：17
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