Synthesis of 4-aryl-2-thioxo-3,4-dihydropyrimidines using a three-component reaction of Meldrum's acid with arylaldehydes and acetylthiourea

被引：2

作者：

Mehrabi, Hossein

Yarahmadi, Tayebeh

Bami, Farzaneh Alizadeh

机构：

[1] Department of Chemistry, Vali-e-Asr University of Rafsanjan, Rafsanjan

来源：

JOURNAL OF CHEMICAL RESEARCH | 2018年 / 06期

关键词：

Meldrum's acid; arylaldehydes; acetylthiourea; p-toluenesulfonic acid; 4-aryl-2-thioxo-3,4-dihydropyrimidincs; ONE-POT SYNTHESIS; SOLVENT-FREE CONDITIONS; BIGINELLI REACTION; REUSABLE CATALYST; BIOLOGICAL EVALUATION; LEWIS-ACID; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; DERIVATIVES; EFFICIENT; DIHYDROPYRIMIDINONES;

D O I：

10.3184/174751918X15293155829494

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot method for the preparation of new 4-aryl-2-thioxo-3,4-dihydropyrimidines via a three-component reaction of Meldrum's acid with arylaldehydes and acetylthiourea in the presence of p-toluenesulfonic acid as catalyst in CH3CN under reflux is reported.

引用

页码：326 / 328

页数：3

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