In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B

被引：5

作者：

Manavathu, EK ^{[1
]}

Cutright, JL ^{[1
]}

Chandrasekar, PH ^{[1
]}

机构：

[1] Wayne State Univ, Dept Internal Med, Div Infect Dis, Detroit, MI 48201 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 01期

关键词：

D O I：

10.1128/AAC.49.1.428-430.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The fungal burdens (number of CFU per pair of lungs) in mice infected AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model.

引用

页码：428 / 430

页数：3

共 7 条

[1] Lack of correlation of in vitro amphotericin B susceptibility testing with outcome in a murine model of Aspergillus infection [J].

Johnson, EM ;

Oakley, KL ;

Radford, SA ;

Moore, CB ;

Warn, P ;

Warnock, DW ;

Denning, DW .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 45 (01) :85-93

[2] In-vitro testing of susceptibility to amphotericin B is a reliable predictor of clinical outcome in invasive aspergillosis [J].

Lass-Flörl, C ;

Kofler, G ;

Kropshofer, G ;

Hermans, J ;

Kreczy, A ;

Dierich, MP ;

Niederwieser, D .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (04) :497-502

[3] In-vitro isolation and antifungal susceptibility of amphotericin B-resistant mutants of Aspergillus fumigatus [J].

Manavathu, EK ;

Alangaden, GJ ;

Chandrasekar, PH .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 41 (06) :615-619

[4] In-vitro and in-vivo susceptibility of Aspergillus fumigatus to a novel conjugated styryl ketone [J].

Manavathu, EK ;

Dimmock, JR ;

Vashishtha, SC ;

Cutright, J ;

Chandrasekar, PH .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (05) :585-590

[5]

National Committee for Clinical Laboratory Standards, 2002, REF METH BROTH DIL A

[6]

Odds FC, 1998, ANTIMICROB AGENTS CH, V42, P282

[7] Efficacy of LY303366 against amphotericin B-susceptible and -resistant Aspergillus fumigatus in a murine model of invasive aspergillosis [J].

Verweij, PE ;

Oakley, KL ;

Morrissey, J ;

Morrissey, G ;

Denning, DW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (04) :873-878

← 1 →