Prognostic value of microRNAs in cervical carcinoma: a systematic review and meta-analysis

被引：19
作者：
Dai, Shengkang [1 ]
Lu, Yan [1 ]
Long, Ying [1 ]
Lai, Yuehua [1 ]
Du, Ping [1 ]
Ding, Nan [1 ]
Yao, Desheng [1 ]
机构：
[1] Guangxi Med Univ, Affiliated Tumor Hosp, Dept Gynecol Oncol, Nanning, Guangxi, Peoples R China
来源：
ONCOTARGET | 2016年 / 7卷 / 23期
关键词：
microRNA; prognosis; cervical carcinoma; meta-analysis; SQUAMOUS-CELL CARCINOMA; POOR-PROGNOSIS; AGGRESSIVE PROGRESSION; CIRCULATING MICRORNA; ABERRANT EXPRESSION; UTERINE CERVIX; CANCER; MARKER; STATISTICS; BIOMARKER;
D O I：
10.18632/oncotarget.9294
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This systematic review is written to investigate the outcome of cervical cancer. A comprehensive search of PubMed and EMBASE was performed to identify eligible studies. Nineteen studies from thirteen articles with a total of 1,310 participants were included in this meta-analysis. Overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) as a prognosis for cervical cancer were extracted and calculated, if available. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using STATA (version 12.0), resulting in the pooled HRs 0.70 (95% CI: 0.51-0.97) for OS, 1.02 (95% CI: 0.53-1.98) for DFS, and 0.56 (95% CI: 0.40-0.77) for RFS. The results indicated that cervical cancer patients with decreased microRNA expression were associated with shorter OS and RFS. It suggested that microRNAs might be promising markers for predicting the survival rate of cervical cancer.
引用
收藏
页码：35369 / 35378
页数：10
相关论文
共 30 条
[1]  
[Anonymous], TUMOUR BIOL
[2]   Prognostic value of microRNAs in acute myocardial infarction: A systematic review and meta-analysis [J].
Cao, Wenzhai ;
Guo, Qiang ;
Zhang, Ting ;
Zhong, DeChao ;
Yu, Qian .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2015, 189 :79-84
[3]   Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma [J].
Chen, Junying ;
Yao, Desheng ;
Li, Yue ;
Chen, Hong ;
He, Chanjuan ;
Ding, Nan ;
Lu, Yan ;
Ou, Tingyu ;
Zhao, Shan ;
Li, Li ;
Long, Fengyi .
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2013, 32 (03) :557-567
[4]   Bias in meta-analysis detected by a simple, graphical test [J].
Egger, M ;
Smith, GD ;
Schneider, M ;
Minder, C .
BMJ-BRITISH MEDICAL JOURNAL, 1997, 315 (7109) :629-634
[5]   Regulation of microRNA biogenesis [J].
Ha, Minju ;
Kim, V. Narry .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (08) :509-524
[6]   Prognostic significance of low DICER expression regulated by miR-130a in cervical cancer [J].
He, L. ;
Wang, H-Y ;
Zhang, L. ;
Huang, L. ;
Li, J-D ;
Xiong, Y. ;
Zhang, M-Y ;
Jia, W-H ;
Yun, J-P ;
Luo, R-Z ;
Zheng, M. .
CELL DEATH & DISEASE, 2014, 5 :e1205-e1205
[7]   PROGNOSTIC VALUE OF PRETREATMENT CARCINOEMBRYONIC ANTIGEN AFTER DEFINITIVE RADIOTHERAPY WITH OR WITHOUT CONCURRENT CHEMOTHERAPY FOR SQUAMOUS CELL CARCINOMA OF THE UTERINE CERVIX [J].
Huang, Eng-Yen ;
Hsu, Hsuan-Chih ;
Sun, Li-Min ;
Chanchien, Chan-Chao ;
Lin, Hao ;
Chen, Hui-Chun ;
Tseng, Chih-Wen ;
Ou, Yu-Che ;
Chang, Hung-Yao ;
Fang, Fu-Min ;
Huang, Yu-Jie ;
Wang, Chang-Yu ;
Lu, Hsien-Ming ;
Tsai, Ching-Chou ;
Ma, Yen-Ying ;
Fu, Hung-Chun ;
Wang, Yu-Ming ;
Wang, Chong-Jong .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2011, 81 (04) :1105-1113
[8]   Downregulation of Six MicroRNAs Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix [J].
Huang, Long ;
Lin, Jia-Xin ;
Yu, Yan-Hong ;
Zhang, Mei-Yin ;
Wang, Hui-Yun ;
Zheng, Min .
PLOS ONE, 2012, 7 (03)
[9]   Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis [J].
Kosaka, Nobuyoshi ;
Iguchi, Haruhisa ;
Ochiya, Takahiro .
CANCER SCIENCE, 2010, 101 (10) :2087-2092
[10]   MicroRNA-215 is a potential prognostic marker for cervical cancer [J].
Liang, Hua ;
Li, Yan ;
Luo, Ruo-yu ;
Shen, Fu-jin .
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2014, 34 (02) :207-212
123