Male breast cancer: a review of clinical management

被引:105
作者
Agrawal, A. [1 ]
Ayantunde, A. A. [1 ]
Rampaul, R. [1 ]
Robertson, J. F. R. [1 ]
机构
[1] Univ Nottingham, City Hosp, Surg Unit, Nottingham NG5 1PB, England
关键词
breast cancer; male; aetiology; pathology; treatment;
D O I
10.1007/s10549-006-9356-z
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aims Male breast cancer incidence is 1% of all breast cancers and is increasing. We aim to present an overview of male breast cancer with particular emphasis on clinical management. Methods Studies were identified by an online search of literature in the MEDLINE database till June 2006 followed by an extensive review of bibliographies. Results Increased risk factors include genetic predisposition as in BRCA2 families; testicular dysfunction due to chromosomal abnormality such as Klinefelter's syndrome or environmental factors such as chronic heat exposure and radiation. Clinical assessment with biopsy is the hallmark of diagnosis. Earlier presentations are becoming commoner but there are wide geographical differences. Surgical treatment involves simple or modified radical mastectomy along with surgical assessment of the axilla, either via sentinel node biopsy in clinically node-negative disease or axillary sampling/clearance in node-positive disease. Reconstructions for restoring body image have been recently reported. Indications for adjuvant therapies are similar to that in women. For metastatic disease, tamoxifen is still the mainstay for oestrogen receptor positive disease. For oestrogen receptor negative disease, doxorubicin based chemotherapy regimens are used. In addition, the oft neglected psychological aspects of men having a "cancer of women" are increasingly being recognised. Conclusions There is, thus, need for further increasing awareness among men to reduce stigma associated with presentation of symptoms related to breast. This should be in addition to stressing to clinicians the ways of earlier detection and tailor-made "gender oriented" treatment of breast cancer in men.
引用
收藏
页码:11 / 21
页数:11
相关论文
共 158 条
  • [31] DETRAUX P, 1983, RADIOLOGY, V154, P605
  • [32] Carcinoma of the male breast: An underestimated killer
    Di Benedetto, G
    Pierangeli, M
    Bertani, A
    [J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 1998, 102 (03) : 696 - 700
  • [33] DOBERAUER C, 1988, CANCER, V62, P474, DOI 10.1002/1097-0142(19880801)62:3<474::AID-CNCR2820620305>3.0.CO
  • [34] 2-2
  • [35] Breast cancer in men
    Donegan, WL
    Redlich, PN
    [J]. SURGICAL CLINICS OF NORTH AMERICA, 1996, 76 (02) : 343 - &
  • [36] Donegan WL, 1998, CANCER-AM CANCER SOC, V83, P498, DOI 10.1002/(SICI)1097-0142(19980801)83:3<498::AID-CNCR19>3.0.CO
  • [37] 2-R
  • [38] Men with breast cancer have better disease-specific survival than women
    El-Tamer, MB
    Komenaka, IK
    Troxel, A
    Li, HL
    Joseph, KA
    Ditkoff, BA
    Schnabel, FR
    Kinne, DW
    [J]. ARCHIVES OF SURGERY, 2004, 139 (10) : 1079 - 1082
  • [39] MALE BREAST-CANCER - A 13-YEAR REVIEW OF 89 PATIENTS
    ERLICHMAN, C
    MURPHY, KC
    ELHAKIM, T
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1984, 2 (08) : 903 - 909
  • [40] Risk factors for male breast cancer - A case-control study from Scandinavia
    Ewertz, M
    Holmberg, L
    Tretli, S
    Pedersen, BV
    Kristensen, A
    [J]. ACTA ONCOLOGICA, 2001, 40 (04) : 467 - 471