Cellular expression of the cytolytic factor in earthworms Eisenia foetida

被引：45
作者：
Bilej, M
Rossmann, P
Sinkora, M
Hanusová, R
Beschin, A
Raes, G
De Baetselier, P
机构：
[1] Acad Sci Czech Republ, Inst Microbiol, Dept Immunol, CR-14220 Prague 4, Czech Republic
[2] Charles Univ Prague, Fac Sci, Prague 2, Czech Republic
[3] Free Univ Brussels VIB, Unit Cellular Immunol, B-1640 Rhode St Genese, Belgium
来源：
IMMUNOLOGY LETTERS | 1998年 / 60卷 / 01期
关键词：
Eisenia foetida; coelomic fluid; coelomic cytolytic factor 1 (CCF-1); lipopolysaccharide; TNF; coelomocytes; chloragogenous tissue;
D O I：
10.1016/S0165-2478(97)00127-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Coelomic fluid of earthworms contains a 42 kDa protein designated CCF-1 (coelomic cytolytic factor 1), which accounts for approximately 40% of cytolytic activity of the entire coelomic fluid. CCF-1 was documented to be present on cells of the mesenchymal lining of the coelomic cavity as well as on free coelomocytes. Both cellular and humoral levels of CCF-1 were significantly increased after parenteral injection of endotoxin. Moreover, CCF-1 seems to be involved in cell mediated cytotoxicity, because cytotoxic activity is blocked in the presence of anti-CCF-1 monoclonal antibody (mAb). (C) 1998 Elsevier Science B.V.
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页码：23 / 29
页数：7
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