Preparation of 5-fluorouracil loaded chitosan microparticle and its drug release properties

被引：0

作者：

Li, Mingming ^{[1
]}

Zhan, Shiping ^{[1
]}

机构：

[1] Dalian Univ, Dept Environm & Chem Engn, Dalian, Peoples R China

来源：

2016 INTERNATIONAL CONFERENCE ON MEDICINE SCIENCES AND BIOENGINEERING (ICMSB2016) | 2017年 / 8卷

关键词：

D O I：

10.1051/bioconf/20170801058

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chitosan is one kind of good biocompatible polymer and is suitble for drug carriers. Preparation of 5-fluorouracil (5-Fu) loaded chitosan (CS) particles and in vitro release experiment were performed using ionic crosslinking method with sodium tripolyphosphate (TPP) as crosslinker. The optimal preparing parameters were verified by 5-Fu release experiments. The drug loading, and release behavior of drug loaded microparticles in vitro were investigated. The optimal preparation conditions were: the temperature 25 degrees C, the ratio of CS to TPP 5:1 the CS concentration 1.5g/L, stirring speed 650rpm. Under these conditions, the drug loading of particles was up to 45%.

引用

页数：5

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