Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever

被引：4

作者：

Karaman, Kayihan ^{[1
]}

Karayakali, Metin ^{[1
]}

Erken, Ertugrul ^{[1
]}

Demirtas, Ahmet ^{[1
]}

Ozturk, Mustafa ^{[1
]}

Altunkas, Fatih ^{[1
]}

Arisoy, Arif ^{[1
]}

Turan, Oguzhan Ekrem ^{[1
]}

Ceyhan, Koksal ^{[1
]}

Celik, Atac ^{[1
]}

机构：

[1] Gaziosmanpasa Univ, Dept Cardiol, Sch Med, Tokat, Turkey

来源：

CARDIOVASCULAR JOURNAL OF AFRICA | 2017年 / 28卷 / 03期

关键词：

familial Mediterranean fever; myocardial repolarisation; cTp-Te interval; cTp-Te/QT ratio; TORSADES-DE-POINTES; TP-E/QT RATIO; QT DISPERSION; DIASTOLIC FUNCTION; END INTERVAL; RISK; INDEX; PEAK; ATHEROSCLEROSIS; ARRHYTHMIAS;

D O I：

10.5830/CVJA-2016-074

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Familial Mediterranean fever (FMF) is a chronic, recurrent auto-inflammatory disease characterised by self-terminating attacks of fever and sterile polyserositis. The main cause of death in auto-inflammatory diseases is cardiovascular events. Additionally, auto-inflammatory diseases have potential effects on the myocardial repolarisation parameters, including the T-wave peak-to-end (Tp-Te) interval, cTp-Te interval (corrected Tp-Te) and the cTp-Te/QT ratio. The aim of this study was to analyse the efficacy of myocardial repolarisation alterations in anticipation of cardiovascular risks in patients with FMF. Methods: This study included 66 patients with FMF and 58 healthy control subjects. Tp-Te and cTp-Te intervals and the cTp-Te/QT ratio were measured from the 12-lead electrocardiogram. Results: In electrocardiographic parameters, analysis of QT, QT dispersion, corrected QT (QTc) and QTc dispersion were similar between the groups. The Tp-Te and cTp-Te intervals and Tp-Te/QT and cTp-Te/QT ratios were significantly prolonged in FMF patients. Multivariate linear regression analyses indicated that erythrocyte sedimentation rate was an independent predictor of a prolonged cTp-Te interval. Conclusions: Our study revealed that when compared with control subjects, Tp-Te and cTp-Te intervals and cTp-Te/QT ratio were increased in FMF patients.

引用

页码：154 / 158

页数：5

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