Synthesis of 1,4-enyne-3-ones via palladium-catalyzed sequential decarboxylation and carbonylation of allyl alkynoates

被引：14
|
作者：
Li, Zun [1 ]
Zheng, Jia [1 ]
Hu, Weigao [1 ]
Li, Jianxiao [1 ]
Wu, Wanqing [1 ]
Jiang, Huanfeng [1 ]
机构：
[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 07期
基金：
中国国家自然科学基金;
关键词：
ISOCYANIDE INSERTION; MULTICOMPONENT REACTION; NITROGEN-HETEROCYCLES; ORGANIC-SYNTHESIS; CASCADE REACTIONS; CYCLIZATION; ISONITRILE; DERIVATIVES; ANNULATION; INDOLES;
D O I：
10.1039/c7qo00082k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we describe a novel protocol for the rapid assembly of 1,4-enyne-3-ones from isocyanides and 1,6-enyne. During this process, two different types of C-C bonds were formed on the same isocyanide carbon atom via sequential decarboxylation, insertion of isocyanide, and reductive elimination. Moreover, this approach shows advantages of mild reaction conditions and excellent functional group compatibility.
引用
收藏
页码：1363 / 1366
页数：4
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