β-lactam resistance in Haemophilus parasuis is mediated by plasmid pB1000 bearing blaROB-1

被引：61

作者：

San Millan, Alvaro ^{[1
]}

Escudero, Jose Antonio ^{[1
]}

Catalan, Ana ^{[1
]}

Nieto, Silvia ^{[1
]}

Farelo, Fidel ^{[1
]}

Gibert, Magdalena ^{[1
]}

Moreno, Miguel Angel ^{[1
]}

Dominguez, Lucas ^{[1
]}

Gonzalez-Zorn, Bruno ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Vet, Dept Sanidad Anim, E-28040 Madrid, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 06期

关键词：

D O I：

10.1128/AAC.00242-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

beta-Lactam resistance in Haemophilus parasuis is an emerging phenomenon that has not yet been characterized from a molecular perspective. Clinical high-level beta-lactam-resistant isolates from Spain bore a novel plasmid, pB1000, expressing a functionally active ROB-1 beta-lactamase. Pulsed-field gel electrophoresis was applied for the first time to H. parasuis and showed that beta-lactam resistance is due to clonal spread of a resistant strain, BB1018, bearing pB1000.

引用

页码：2260 / 2264

页数：5

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