Regenerating optic pathways from the eye to the brain

被引：139

作者：

Laha, Bireswar ^{[1
]}

Stafford, Ben K. ^{[1
]}

Huberman, Andrew D. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Ophthalmol, Sch Med, Stanford, CA 94305 USA

[3] Stanford Univ, BioX, Sch Med, Stanford, CA 94305 USA

来源：

SCIENCE | 2017年 / 356卷 / 6342期

关键词：

RETINAL GANGLION-CELLS; PROMOTING AXON REGENERATION; NERVE REGENERATION; NOGO RECEPTOR; STEM-CELLS; ADULT CNS; GROWTH; NEURONS; CONNECTIVITY; INHIBITION;

D O I：

10.1126/science.aal5060

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Humans are highly visual. Retinal ganglion cells (RGCs), the neurons that connect the eyes to the brain, fail to regenerate after damage, eventually leading to blindness. Here, we review research on regeneration and repair of the optic system. Intrinsic developmental growth programs can be reactivated in RGCs, neural activity can enhance RGC regeneration, and functional reformation of eye-to-brain connections is possible, even in the adult brain. Transplantation and gene therapy may serve to replace or resurrect dead or injured retinal neurons. Retinal prosthetics that can restore vision in animal models may too have practical power in the clinical setting. Functional restoration of sight in certain forms of blindness is likely to occur in human patients in the near future.

引用

页码：1031 / 1034

页数：4

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