Alveolar ridge augmentation in irradiated rabbit mandibles

被引：9
作者：
Jegoux, Franck [1 ]
Aguado, Eric [2 ,3 ]
Cognet, Ronan [2 ]
Malard, Olivier [1 ]
Moreau, Francoise [4 ]
Daculsi, Guy [1 ,5 ]
Goyenvalle, Eric [2 ,3 ]
机构：
[1] Fac Med, INSERM, U791, Nantes, France
[2] Nantes Vet Sch, LBBTO Ex, Nantes, France
[3] Fac Med, INSERM 0335, Angers, France
[4] Biomatlante, Vigneux De Bretagne, France
[5] Ctr Hosp Univ, CIC CIT, Bordeaux, France
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2010年 / 93A卷 / 04期
关键词：
calcium phosphate ceramic; oral carcinoma; bone marrow graft; radiotherapy; alveolar ridge augmentation; rabbit; dental implant; GUIDED BONE REGENERATION; MESENCHYMAL STEM-CELLS; CALCIUM-PHOSPHATE SCAFFOLD; COLLAGEN MEMBRANE; IMPLANT SURVIVAL; CANCER-PATIENTS; MARROW GRAFT; DEFECTS; MODEL; SURGERY;
D O I：
10.1002/jbm.a.32644
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Oral carcinomas are frequently treated with a nonsegmental mandibulectomy plus radiotherapy. Improving the quality of life of these patients depends on the possibilities for dental rehabilitation. The aim of this study was to increase the alveolar ridge height. Twelve white New Zealand rabbits underwent surgery to produce a 11 X 9 X 7 mm(3) horizontal bicortical full-thickness defect at the alveolar ridge of the left mandible. Six were implanted with a composite associating resorbable collagen membrane filled with micro-macroporous biphasic calcium phosphate granules. After a daily radiation delivery schedule for 4 weeks, a total autologous bone marrow graft was injected percutaneously into the center of the implant. All animals were sacrificed at 16 weeks. Successful osseous colonization was observed in all implants. Significant ridge augmentation was observed (p = 0.0349) in the implanted group compared with the control group. This study contributed to producing an experimental model for oncological mandible defects. in rabbits. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 93A: 1519-1526, 2010
引用
收藏
页码：1519 / 1526
页数：8
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