Pattern Recognition Receptors and Inflammation

被引：7140

作者：

Takeuchi, Osamu ^{[1
,2
]}

Akira, Shizuo ^{[1
,2
]}

机构：

[1] Osaka Univ, Host Def Lab, WPI Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

来源：

CELL | 2010年 / 140卷 / 06期

关键词：

INNATE IMMUNE-RESPONSE; TOLL-LIKE RECEPTOR-3; DOUBLE-STRANDED-RNA; INDEPENDENT ANTIVIRAL RESPONSE; AICARDI-GOUTIERES-SYNDROME; APOPTOTIC DNA-DEGRADATION; GENE INDUCTION-PROGRAM; ZINC-FINGER PROTEIN; RIG-I HELICASE; DENDRITIC CELLS;

D O I：

10.1016/j.cell.2010.01.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Infection of cells by microorganisms activates the inflammatory response. The initial sensing of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll-like receptors, RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors. The intracellular signaling cascades triggered by these PRRs lead to transcriptional expression of inflammatory mediators that coordinate the elimination of pathogens and infected cells. However, aberrant activation of this system leads to immunodeficiency, septic shock, or induction of autoimmunity. In this Review, we discuss the role of PRRs, their signaling pathways, and how they control inflammatory responses.

引用

页码：805 / 820

页数：16

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