Palladium-Catalyzed Ring-Expansion Reaction of Indoles with Alkynes: From Indoles to Tetrahydroquinoline Derivatives Under Mild Reaction Conditions

被引：87

作者：

Shi, Zhuangzhi ^{[1
]}

Zhang, Bo ^{[1
]}

Cui, Yuxin ^{[1
]}

Jiao, Ning ^{[1
,2
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

[2] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 24期

基金：

美国国家科学基金会;

关键词：

alkynes; C-H activation; indoles; oxidation; palladium; POLYCYCLIC AROMATIC-HYDROCARBONS; H BOND FUNCTIONALIZATION; C-C; OXIDATIVE CYCLIZATION; DIOXYGEN ACTIVATION; MOLECULAR-OXYGEN; ARYLATION; CARBON; ALKENYLATION; ANNULATION;

D O I：

10.1002/anie.201001237

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) A cut and shut job: The highly selective title reaction proceeds, using O2 as the oxidant, to afford tetrahydroquinoline derivatives. This chemistry offers a new approach to polysubstituted 4, 5-dihydrocyclopenta[c]quinolines, and also valuable mechanistic insight into this ring-expansion reaction. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4036 / 4041

页数：6

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