Synthesis of the C9-C29 fragments of ajudazols A and B

被引：16

作者：

Ganame, Danny ^{[1
]}

Quach, Tim ^{[1
]}

Poole, Charlotte ^{[1
]}

Rizzacasa, Mark A. ^{[1
]}

机构：

[1] Univ Melbourne, Inst Biol 2, Sch Chem, Melbourne, Vic 3010, Australia

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 33期

基金：

澳大利亚研究理事会;

关键词：

D O I：

10.1016/j.tetlet.2007.06.072

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of both C9-C29 fragments 3 and 4 of the myxobacteria metabolites ajudazols A (1) and B (2) are described. The key steps were a cyclodehydration to form the oxazole, Sonogashira coupling to form the C18-C19 bond and a P-2 Ni mediated partial alkyne hydrogenation to install the C17-C18 Z-alkene. The C15 alkene in the ajudazol A fragnient 3 was introduced in the final steps by elimination of the corresponding primary alcohol. Crown Copyright (c) 2007 Published by Elsevier Ltd. All rights reserved.

引用

页码：5841 / 5843

页数：3

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