Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application

被引：194
作者：
Yuan, Xun [1 ]
Wu, Hua [1 ]
Han, Na [1 ]
Xu, Hanxiao [1 ]
Chu, Qian [1 ]
Yu, Shiying [1 ]
Chen, Yuan [1 ]
Wu, Kongming [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, Bldg 303,1095 Jie Fang Ave, Wuhan 430030, Peoples R China
来源：
JOURNAL OF HEMATOLOGY & ONCOLOGY | 2014年 / 7卷
基金：
美国国家科学基金会;
关键词：
Notch signaling; Epithelial-mesenchymal transition (EMT); Cancer stem cells (CSCs); Non-small-cell lung cancer (NSCLC); Gamma secretase inhibitor; EPITHELIAL-MESENCHYMAL TRANSITION; GAMMA-SECRETASE INHIBITOR; CYCLIN D1; TGF-BETA; POOR-PROGNOSIS; TUMOR-GROWTH; STEM-CELLS; E-CADHERIN; IN-VITRO; PHASE-I;
D O I：
10.1186/s13045-014-0087-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Through epithelial-mesenchymal transition (EMT), cancer cells acquire enhanced ability of migration and invasion, stem cell like characteristics and therapeutic resistance. Notch signaling regulates cell-cell connection, cell polarity and motility during organ development. Recent studies demonstrate that Notch signaling plays an important role in lung cancer initiation and cross-talks with several transcriptional factors to enhance EMT, contributing to the progression of non-small cell lung cancer (NSCLC). Correspondingly, blocking of Notch signaling inhibits NSCLC migration and tumor growth by reversing EMT. Clinical trials have showed promising effect in some cancer patients received treatment with Notch1 inhibitor. This review attempts to provide an overview of the Notch signal in NSCLC: its biological significance and therapeutic application.
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页数：10
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