Magnetic nanoemulsions as drug delivery system for Foscan®:: Skin permeation and retention in vitro assays for topical application in photodynamic therapy (PDT) of skin cancer

被引：45
作者：
Primo, Fernando L.
Michieleto, Leandro
Rodrigues, Marcilene A. M.
Macaroff, Patricia P.
Morais, Paulo C.
Lacava, Zulmira G. M.
Bentley, Maria Vitoria L. B.
Tedesco, Antonio C. [1 ]
机构：
[1] Univ Sao Paulo, FFCLRP, Dept Quim, BR-14040901 Ribeirao Preto, SP, Brazil
[2] Univ Brasilia, Inst Fis, BR-70919970 Brasilia, DF, Brazil
[3] Univ Brasilia, Inst Ciencias Biol, BR-70910900 Brasilia, DF, Brazil
[4] Univ Sao Paulo, FCFRP, Dept Ciencias Farmaceut, BR-14040901 Ribeirao Preto, SP, Brazil
来源：
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2007年 / 311卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
biocompatible magnetic fluid; skin permeation; magnetic nanoemulsion; hyperthermia; photodynamic therapy;
D O I：
10.1016/j.jmmm.2006.10.1183
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In this work, we performed the synthesis and in vitro characterization of a new class of drug delivery system (DDS) denominated magnetic nanoemulsion (MNE). The association of colloidal nanoparticles with biocompatible magnetic fluids results in a new DDS for application in photodynamic therapy (PDT) and magnetic hyperthermia treatment. It works in a synergic manner with an expected enhancement in tumor damage after minimum drug doses, based on heat dissipation and/or light photosensitization. For this purpose, we investigated the permeation and retention in vitro model using Foscan (R) as a photosensitizer incorporated in MNE using a Franz diffusion cell and a biological skin model in biomimetic conditions. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：354 / 357
页数：4
相关论文
共 16 条
[1]  
BANKUZIS AF, 2005, J MAGN MAGN MATER, V285, P145
[2]   Microemulsions for topical delivery of 8-methoxsalen [J].
Baroli, B ;
López-Quintela, MA ;
Delgado-Charro, MB ;
Fadda, AM ;
Blanco-Méndez, J .
JOURNAL OF CONTROLLED RELEASE, 2000, 69 (01) :209-218
[3]   Photodynamic therapy in head and neck cancer. [J].
Biel M.A. .
Current Oncology Reports, 2002, 4 (1) :87-96
[4]  
Bonnett R., 2000, CHEM ASPECTS PHOTODY, V1
[5]  
DCRUZ AK, 2004, HEAD NECK MAR, P89
[6]   In vitro skin permeation and retention of 5-aminolevulinic acid ester derivatives for photodynamic therapy [J].
De Rosa, FS ;
Tedesco, AC ;
Lopez, RFV ;
Pierre, MBR ;
Lange, N ;
Marchetti, JM ;
Rotta, JCG ;
Bentley, MVLB .
JOURNAL OF CONTROLLED RELEASE, 2003, 89 (02) :261-269
[7]  
Florence A.T., 2003, PHYSICOCHEMICAL PRIN, V3rd
[8]   Effects of AC magnetic field and carboxymethyldextran-coated magnetite nanoparticles on mice peritoneal cells [J].
Guedes, MHA ;
Sadeghiani, N ;
Peixoto, DLG ;
Coelho, JP ;
Barbosa, LS ;
Azevedo, RB ;
Kückelhaus, S ;
Da Silva, MD ;
Morais, PC ;
Lacava, ZGM .
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2005, 293 (01) :283-286
[9]   Use of magnetic resonance to study biodistribution of dextran-coated magnetic fluid intravenously administered in mice [J].
Lacava, LM ;
Lacava, ZGM ;
Azevedo, RB ;
Chaves, SB ;
Garcia, VAP ;
Silva, O ;
Pelegrini, F ;
Buske, N ;
Gansau, C ;
Da Silva, MF ;
Morais, PC .
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2002, 252 (1-3) :367-369
[10]   Zinc tetranitrophthalocyanine: isomer separation and photophysical photobiological evaluation in J774A tumor cells [J].
Lunardi, CN ;
Rotta, JCG ;
Tedesco, AC .
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 2003, 7 (07) :493-499
12