Prognostic factors influencing prognosis in early breast cancer patients

被引:13
作者
Najafi, Safa [1 ]
Sadeghi, Masoud [2 ]
Abasvandi, Fereshteh [1 ]
Shajari, Mohammad Reza [1 ]
Mohebi, Kamran [1 ]
Ghandchi, Helen [1 ]
机构
[1] ACECR, Motamed Canc Inst, Breast Dis Dept, Breast Canc Res Ctr, Tehran, Iran
[2] Kermanshah Univ Med Sci, Med Biol Res Ctr, POB 67155-1616, Kermanshah, Iran
来源
MENOPAUSE REVIEW-PRZEGLAD MENOPAUZALNY | 2019年 / 18卷 / 02期
关键词
early breast cancer; survival; recurrence; prognosis; SURVIVAL; ASSOCIATION; SUBTYPES; COHORT; IRAN;
D O I
10.5114/pm.2019.86833
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Aim of the study: The present study showed the clinicopathological characteristics and survival of early breast cancer (BC) patients. Material and methods: A total of 236 patients were included in the study. The mean follow-up time was 59.5 months (range: 12-204 months). The inclusion criteria consisted of female patients aged > 20 years and early BC patients (stages I and IIA). Results: The mean age at diagnosis was 51.2 years (range, 23-83 years), and 55.9% of patients were aged >= 50 years. Most patients (92.8%) did not have lymph node metastasis, and luminal B had the highest prevalence (54.2%) in patients. The eight-year overall survival (OS) and disease-free survival (DFS) rates were 98.3% and 92.3%, respectively. Stage IIA and Ki67 index >= 14% were more prevalent in the patients with tumour size of 2 <= T <= 5 cm compared to another tumour size group and Ki67 index. Conclusions: The mean age at diagnosis in this study was in agreement with other studies reported in various areas, but with a higher percentage for elderly patients compared to some previous studies. In addition, the survival rate in the present study was higher than the results of previous studies. Future studies need to investigate these factors in a higher number of patients and in different areas and should select similar stages for early BC.
引用
收藏
页码:82 / 88
页数:7
相关论文
共 27 条
[1]  
Abedi Ghasem, 2016, Asian Pac J Cancer Prev, V17, P4615
[2]   A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities [J].
Abraham, Jean E. ;
Hiller, Louise ;
Dorling, Leila ;
Vallier, Anne-Laure ;
Dunn, Janet ;
Bowden, Sarah ;
Ingle, Susan ;
Jones, Linda ;
Hardy, Richard ;
Twelves, Christopher ;
Poole, Christopher J. ;
Pharoah, Paul D. P. ;
Caldas, Carlos ;
Earl, Helena M. .
BMC MEDICINE, 2015, 13
[3]   Association between age and survival in a cohort of Brazilian patients with operable breast cancer [J].
Balabram, Debora ;
Turra, Cassio M. ;
Gobbi, Helenice .
CADERNOS DE SAUDE PUBLICA, 2015, 31 (08) :1732-1742
[4]   Immunophenotype and evolution of breast carcinomas: a comparison between very young and postmenopausal women [J].
Dutra, Mara Costa ;
Rezende, Marina Alvarenga ;
de Andrade, Victor Piana ;
Soares, Fernando Augusto ;
Ribeiro, Marcio Ventura ;
de Paula, Elbio Candido ;
Gobbi, Helenice .
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA, 2009, 31 (02) :54-60
[5]  
Enayatrad M, 2015, IRAN J PUBLIC HEALTH, V44, P430
[6]   The clinical prognostic value of molecular intrinsic tumor subtypes in older breast cancer patients: A FOCUS study analysis [J].
Engels, Charla C. ;
Kiderlen, Mandy ;
Bastiaannet, Esther ;
Mooyaart, Antien L. ;
van Vlierberghe, Ronald ;
Smit, Vincent T. H. B. M. ;
Kuppen, Peter J. K. ;
van de Velde, Cornelis J. H. ;
Liefers, G. J. .
MOLECULAR ONCOLOGY, 2016, 10 (04) :594-600
[7]  
Hunt KK, 2015, SCHWARTZ PRINCIPLES
[8]   Treatment of Early Breast Cancer, a Long-term Follow-up Study: The GOCS Experience [J].
Iturbe, Julian ;
Zwenger, Ariel ;
Leone, Jose Pablo ;
Perez Verdera, Palmira ;
Vallejo, Carlos ;
Romero, Alberto ;
Perez, Juan ;
Machiavelli, Mario ;
Leone, Bernardo .
BREAST JOURNAL, 2011, 17 (06) :630-637
[9]   Incidence of primary breast cancer in Iran: Ten-year national cancer registry data report [J].
Jazayeri, Seyed Behzad ;
Saadat, Soheil ;
Ramezani, Rashid ;
Kaviani, Ahmad .
CANCER EPIDEMIOLOGY, 2015, 39 (04) :519-527
[10]   The prognostic role of tumor size in early breast cancer in the era of molecular biology [J].
Kasangian, Anaid Anna ;
Gherardi, Giorgio ;
Biagioli, Elena ;
Torri, Valter ;
Moretti, Anna ;
Bernardin, Elena ;
Cordovana, Andrea ;
Farina, Gabriella ;
Bramati, Annalisa ;
Piva, Sheila ;
Dazzani, Maria Chiara ;
Paterno, Emanuela ;
La Verde, Nicla Maria .
PLOS ONE, 2017, 12 (12)