Macrophage-epithelial interactions in pulmonary alveoli

被引：63

作者：

Bhattacharya, Jahar ^{[1
,2
]}

Westphalen, Kristin ^{[3
,4
]}

机构：

[1] Columbia Univ, Dept Med, New York, NY USA

[2] Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY USA

[3] Univ Munich, Dept Anesthesiol, Munich, Germany

[4] German Ctr Lung Res DZL, CPC, Munich, Germany

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2016年 / 38卷 / 04期

关键词：

TOLL-LIKE RECEPTOR; INDUCED ACUTE LUNG; KAPPA-B ACTIVATION; INFLAMMATORY PROTEIN-1-ALPHA; BRONCHOALVEOLAR LAVAGE; DIPHTHERIA-TOXIN; IRAK-M; KINASE; LIPOPOLYSACCHARIDE; INJURY;

D O I：

10.1007/s00281-016-0569-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alveolar macrophages have been investigated for years by approaches involving macrophage extraction from the lung by bronchoalveolar lavage, or by cell removal from lung tissue. Since extracted macrophages are studied outside their natural milieu, there is little understanding of the extent to which alveolar macrophages interact with the epithelium, or with one another to generate the lung's innate immune response to pathogen challenge. Here, we review new evidence of macrophage-epithelial interactions in the lung, and we address the emerging understanding that the alveolar epithelium plays an important role in orchestrating the macrophage-driven immune response.

引用

页码：461 / 469

页数：9

共 80 条

[1] Diverse macrophage populations mediate acute lung inflammation and resolution [J].

Aggarwal, Neil R. ;

King, Landon S. ;

D'Alessio, Franco R. .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2014, 306 (08) :L709-L725

[2] Secretion of IL-16 through TNFR1 and calpain-caspase signaling contributes to MRSA pneumonia [J].

Ahn, D. S. ;

Parker, D. ;

Planet, P. J. ;

Nieto, P. A. ;

Bueno, S. M. ;

Prince, A. .

MUCOSAL IMMUNOLOGY, 2014, 7 (06) :1366-1374

[3] The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs [J].

Androulidaki, Ariadne ;

Iliopoulos, Dimitrios ;

Arranz, Alicia ;

Doxaki, Christina ;

Schworer, Steffen ;

Zacharioudaki, Vassiliki ;

Margioris, Andrew N. ;

Tsichlis, Philip N. ;

Tsatsanis, Christos .

IMMUNITY, 2009, 31 (02) :220-231

[4] Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage [J].

Angulo, Ivan ;

Vadas, Oscar ;

Garcon, Fabien ;

Banham-Hall, Edward ;

Plagnol, Vincent ;

Leahy, Timothy R. ;

Baxendale, Helen ;

Coulter, Tanya ;

Curtis, James ;

Wu, Changxin ;

Blake-Palmer, Katherine ;

Perisic, Olga ;

Smyth, Deborah ;

Maes, Mailis ;

Fiddler, Christine ;

Juss, Jatinder ;

Cilliers, Deirdre ;

Markelj, Gasper ;

Chandra, Anita ;

Farmer, George ;

Kielkowska, Anna ;

Clark, Jonathan ;

Kracker, Sven ;

Debre, Marianne ;

Picard, Capucine ;

Pellier, Isabelle ;

Jabado, Nada ;

Morris, James A. ;

Barcenas-Morales, Gabriela ;

Fischer, Alain ;

Stephens, Len ;

Hawkins, Phillip ;

Barrett, Jeffrey C. ;

Abinun, Mario ;

Clatworthy, Menna ;

Durandy, Anne ;

Doffinger, Rainer ;

Chilvers, Edwin R. ;

Cant, Andrew J. ;

Kumararatne, Dinakantha ;

Okkenhaug, Klaus ;

Williams, Roger L. ;

Condliffe, Alison ;

Nejentsev, Sergey .

SCIENCE, 2013, 342 (6160) :866-871

[5] [Ca2+]i oscillations regulate type II cell exocytosis in the pulmonary alveolus [J].

Ashino, Y ;

Ying, XY ;

Dobbs, LG ;

Bhattacharya, J .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2000, 279 (01) :L5-L13

[6] ALVEOLAR LINING LAYER IS THIN AND CONTINUOUS - LOW-TEMPERATURE SCANNING ELECTRON-MICROSCOPY OF RAT LUNG [J].

BASTACKY, J ;

LEE, CYC ;

GOERKE, J ;

KOUSHAFAR, H ;

YAGER, D ;

KENAGA, L ;

SPEED, TP ;

CHEN, Y ;

CLEMENTS, JA .

JOURNAL OF APPLIED PHYSIOLOGY, 1995, 79 (05) :1615-1628

[7] Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome [J].

Bastarache, Julie A. ;

Fremont, Richard D. ;

Kropski, Jonathan A. ;

Bossert, Frederick R. ;

Ware, Lorraine B. .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2009, 297 (06) :L1035-L1041

[8] Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice [J].

Bem, R. A. ;

Farnand, A. W. ;

Wong, V. ;

Koski, A. ;

Rosenfeld, M. E. ;

van Rooijen, N. ;

Frevert, C. W. ;

Martin, T. R. ;

Matute-Bello, G. .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2008, 295 (02) :L314-L325

[9] CD11C+ ALVEOLAR MACROPHAGES ARE A SOURCE OF IL-23 DURING LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY [J].

Bosmann, Markus ;

Grailer, Jamison J. ;

Russkamp, Norman F. ;

Ruemmler, Robert ;

Zetoune, Firas S. ;

Sarma, J. Vidya ;

Ward, Peter A. .

SHOCK, 2013, 39 (05) :447-452

[10] Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling [J].

Bourdonnay, Emilie ;

Zaslona, Zbigniew ;

Penke, Loka Raghu Kumar ;

Speth, Jennifer M. ;

Schneider, Daniel J. ;

Przybranowski, Sally ;

Swanson, Joel A. ;

Mancuso, Peter ;

Freeman, Christine M. ;

Curtis, Jeffrey L. ;

Peters-Golden, Marc .

JOURNAL OF EXPERIMENTAL MEDICINE, 2015, 212 (05) :729-742

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