Effect of methyl cellulose on gelation behavior and drug release from poloxamer based ophthalmic formulations

被引：55
作者：
Dewan, Mitali [1 ]
Bhowmick, Biplab [1 ]
Sarkar, Gunjan [1 ]
Rana, Dipak [2 ]
Bain, Mrinal Kanti [3 ]
Bhowmik, Manas [4 ]
Chattopadhyay, Dipankar [1 ]
机构：
[1] Univ Calcutta, Univ Coll Sci & Technol, Dept Polymer Sci & Technol, Kolkata 700009, India
[2] Univ Ottawa, Ind Membrane Res Inst, Dept Chem & Biol Engn, Ottawa, ON K1N 6N5, Canada
[3] Directorate Tech Educ & Training, Contai Polytech, East Madnapur 721401, W Bengal, India
[4] Sikkim Univ, Himalayan Pharm Inst, East Sikkim 737136, India
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2015年 / 72卷
关键词：
Methyl cellulose; Molecular weight effect; Gelation behavior; Rheological property; In vitro drug release; PLURONIC F-127 GELS; RHEOLOGICAL PROPERTIES; DELIVERY-SYSTEM; SUSTAINED-RELEASE; TEMPERATURE; METHYLCELLULOSE; MICELLIZATION; KINETICS; VEHICLE; MC;
D O I：
10.1016/j.ijbiomac.2014.09.021
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of weight average molecular weight (M-w) of methyl cellulose (MC) on the gelation behavior of Poloxamer 407 (PM) and in vitro release of Ketorolac Tromethamine (KT) from different ophthalmic formulations based on PM is examined. A drop of gelation temperature of PM is observed using MC of various M-w by test tube tilting method, UV-vis spectroscopy, viscometry and rheometry. It is also observed that the viscosity and gel strength of all the formulations are increased with the increase in M-w of MC. PM with highest M-w of MC provides best drug release property among all the formulations. It is evident from this investigation that there is a distinct effect of M-w of MC on the gelation behavior of PM as well as on the drug release profile of KT from PM-MC based ophthalmic formulations. (C) 2014 Elsevier B.V. All rights reserved.
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收藏
页码：706 / 710
页数：5
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