Egyptian herbal tea infusions' antioxidants and their antiproliferative and cytotoxic activities against cancer cells

被引：62

作者：

Elansary, Hosam O. ^{[1
,2
]}

Mahmoud, Eman A. ^{[3
,4
]}

机构：

[1] Univ Guelph, Biodivers Inst Ontario, Guelph, ON N1G 2W1, Canada

[2] Univ Alexandria, Fac Agr El Shatby, Floriculture Ornamental Hort & Garden Design Dept, Mol Biol Lab, Alexandria, Egypt

[3] Univ Guelph, Dept Food Sci, Guelph, ON N1G 2W1, Canada

[4] High Inst Tourism Hotels & Comp, Hotel Studies Dept, Alexandria, Egypt

来源：

NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 05期

关键词：

anticancer; rosemary; marjoram; HPLC; DPPH; mint; ROSMARINUS-OFFICINALIS; LEAF EXTRACTS; OREGANO; THYME; MINT;

D O I：

10.1080/14786419.2014.951354

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The antioxidant, antiproliferative and cytotoxic activities against different human cancer cells were investigated in local and recently introduced plants of Mentha sp., Rosmarinus officinalis L. (ROL) and Origanum majorana L. (OML). ROL exhibited the highest antioxidant activities (IC50 8.4 +/- 0.2 mu g/mL) followed by OML and mint species such as Mentha suaveolens 'apple mint' and Mentha longifolia L. exhibiting moderate antioxidant activities. HPLC analysis of leaf extract revealed that rosmarinic acid is the main component followed by caffeic acid. Herbal leaf extracts varied in their proliferation inhibition and cytotoxicity against HeLa, MCF-7 and Jurkat cancer cells in a dose-dependent matter. The highest antiproliferative inhibition and cytotoxic activity were detected in ROL and OML followed by mint. Local herbs might have a potential role as anticancer natural medicines in addition to their high antioxidant activities due to the presence of different phenolics in their aqueous tea extracts.

引用

页码：474 / 479

页数：6

共 20 条

[1]

Alenzi FQB, 2004, BRIT J BIOMED SCI, V61, P1

[2] Antioxidant activity and free radical-scavenging capacity of ethanolic extracts of thyme, oregano, and marjoram [J].

Amarowicz, Ryszard ;

Zegarska, Zofia ;

Rafalowski, Ryszard ;

Pegg, Ronald B. ;

Karamac, Magdalena ;

Kosinska, Agnieszka .

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 2009, 111 (11) :1111-1117

[3]

[Anonymous], [No title captured]

[4] Ocimum Sanctum L (Holy Basil or Tulsi) and Its Phytochemicals in the Prevention and Treatment of Cancer [J].

Baliga, Manjeshwar Shrinath ;

Jimmy, Rosmy ;

Thilakchand, Karadka Ramdas ;

Sunitha, Venkatesh ;

Bhat, Neeta Raghavendra ;

Saldanha, Elroy ;

Rao, Suresh ;

Rao, Pratima ;

Arora, Rajesh ;

Palatty, Princy L. .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2013, 65 :26-35

[5] Phenolic-storing cells: keys to programmed cell death and periderm formation in wilt disease resistance and in general defence responses in plants? [J].

Beckman, CH .

PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY, 2000, 57 (03) :101-110

[6] Antioxidant potential of curry (Murraya koenigii L.) and mint (Mentha spicata) leaf extracts and their effect on colour and oxidative stability of raw ground pork meat during refrigeration storage [J].

Biswas, A. K. ;

Chatli, M. K. ;

Sahoo, J. .

FOOD CHEMISTRY, 2012, 133 (02) :467-472

[7]

Brian ML, 2006, MINT GENUS MENTHA, P11

[8]

COHEN JJ, 1993, IMMUNOL TODAY, V14, P126, DOI 10.1016/0167-5699(93)90214-6

[9] Phenolic diterpenes, flavones, and rosmarinic acid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis.: Antioxidant activity [J].

del Baño, MJ ;

Lorente, J ;

Castillo, J ;

Benavente-García, O ;

del Río, JA ;

Ortuño, A ;

Quirin, KW ;

Gerard, D .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (15) :4247-4253

[10] Antioxidant properties and composition of aqueous extracts from Mentha species, hybrids, varieties, and cultivars [J].

Dorman, HJD ;

Kosar, M ;

Kahlos, K ;

Holm, Y ;

Hiltunen, R .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (16) :4563-4569

← 1 2 →