The Effect of Divalent Salt in Chondroitin Sulfate Solutions

被引：0
|
作者：
Aranghel, D. [1 ,2 ]
Badita, C. R. [1 ,3 ]
Radulescu, A. [4 ]
Moldovan, L.
Craciunescu, O. [5 ]
Balasoiu, M. [1 ,6 ]
机构：
[1] Horia Hulubei Natl Inst Phys & Nucl Engn, Reactorului 30,POB MG6, RO-077125 Magurele, Romania
[2] Extreme Light Infrastruct Nucl Phys ELI NP, Reactorului 30,POB MG6, RO-077125 Magurele, Romania
[3] Univ Bucharest, Fac Phys, Atomistilor 405,CP MG 11, RO-077125 Magurele, Romania
[4] Forschungszentrum Julich GmbH, Julich Ctr Neutron Sci, D-85747 Garching, Germany
[5] Natl Inst R&D Biol Sci, Splaiul Independenlei 296,Sect 6,CP 17-16, Bucharest 060031, Romania
[6] Joint Inst Nucl Res, Dubna 141980, Moscow Region, Russia
来源：
9TH INTERNATIONAL PHYSICS CONFERENCE OF THE BALKAN PHYSICAL UNION (BPU-9) | 2016年 / 1722卷
关键词：
SMALL-ANGLE SCATTERING;
D O I：
10.1063/1.4944236
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
Chondroitin-4 sulfate (CS4) is the main glycosaminoglycan extracted from bovine trachea. CS4 play an important role in osteoarthritis treatment, anticoagulant activity, reduces the degradation of cartilage matrix components, reduces necrosis and apoptosis of chondrocytes and reduces the activity of collagenase. Chondroitin sulfate is also responsible for proteoglycans degradation. Chondroitin sulfate can bind calcium ions with different affinities, depending on their sulfation position. The purpose of this study was to determine the structural properties and the influence of Ca2+ cations. We carried out measurements on CS4 solutions and mixtures of liquid CS4 with Ca2+ by Small-Angle Neutron Scattering (SANS). CS4 have a mass fractal behavior and the addition of a salt (CaCl2) in CS4 solutions generates the appearance of a correlation peak due to local ordering between adjacent chains with inter-chain distances between 483 angstrom and 233 angstrom for a calcium concentration of 0.01% w/w.
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页数：4
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