The Metabolic Syndrome and Cognitive Decline in the Atherosclerosis Risk in Communities Study (ARIC)

被引：23
|
作者：
Dearborn, Jennifer L. [1 ]
Knopman, David [2 ]
Sharrett, A. Richey [3 ]
Schneider, Andrea L. C. [3 ]
Jack, Clifford R., Jr. [4 ]
Coker, Laura H. [5 ]
Alonso, Alvaro [6 ]
Selvin, Elizabeth [3 ]
Mosley, Thomas H. [7 ]
Wagenknecht, Lynne E. [8 ]
Windham, Beverly G. [7 ]
Gottesman, Rebecca F. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[2] Mayo Clin, Dept Neurol, Rochester, MN USA
[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[4] Mayo Clin, Dept Radiol, Rochester, MN USA
[5] Wake Forest Sch Med, Dept Neurol, Winston Salem, NC USA
[6] Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, Minneapolis, MN USA
[7] Univ Mississippi, Dept Med, Div Geriatr, Sch Med, Jackson, MS USA
[8] Wake Forest Sch Med, Div Publ Hlth Sci, Winston Salem, NC USA
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2014年 / 38卷 / 5-6期
关键词：
Metabolic syndrome; Cognition; Cognitive decline; Obesity; Hypertension; Dementia; CARDIOVASCULAR-DISEASE; DEMENTIA; OBESITY; BRAIN; INFLAMMATION; HYPERTENSION; ASSOCIATION; MIDLIFE; HEALTH;
D O I：
10.1159/000362265
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Background: Midlife metabolic syndrome (MetS) may impact cognitive health as a construct independently of hypertension, hyperlipidemia and other components. Methods: 10,866 participants aged 45-64 years at baseline were assessed for MetS and completed cognitive testing at two later time points (3 and 9 years from the baseline visit). Results: MetS is associated with increased odds of low cognitive performance in the domains of executive function and word fluency, but not with 6-year cognitive decline. Individual MetS components explained this association (hypertension, diabetes, low HDL, elevated triglycerides and increased waist circumference). Conclusions: A focus on the individual risk factors as opposed to MetS during midlife is important to reduce the incidence of cognitive impairment in later life. (C) 2014 S. Karger AG, Basel
引用
收藏
页码：337 / 346
页数：10
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