The Metabolic Syndrome and Cognitive Decline in the Atherosclerosis Risk in Communities Study (ARIC)

被引：23
|
作者：
Dearborn, Jennifer L. [1 ]
Knopman, David [2 ]
Sharrett, A. Richey [3 ]
Schneider, Andrea L. C. [3 ]
Jack, Clifford R., Jr. [4 ]
Coker, Laura H. [5 ]
Alonso, Alvaro [6 ]
Selvin, Elizabeth [3 ]
Mosley, Thomas H. [7 ]
Wagenknecht, Lynne E. [8 ]
Windham, Beverly G. [7 ]
Gottesman, Rebecca F. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[2] Mayo Clin, Dept Neurol, Rochester, MN USA
[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[4] Mayo Clin, Dept Radiol, Rochester, MN USA
[5] Wake Forest Sch Med, Dept Neurol, Winston Salem, NC USA
[6] Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, Minneapolis, MN USA
[7] Univ Mississippi, Dept Med, Div Geriatr, Sch Med, Jackson, MS USA
[8] Wake Forest Sch Med, Div Publ Hlth Sci, Winston Salem, NC USA
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2014年 / 38卷 / 5-6期
关键词：
Metabolic syndrome; Cognition; Cognitive decline; Obesity; Hypertension; Dementia; CARDIOVASCULAR-DISEASE; DEMENTIA; OBESITY; BRAIN; INFLAMMATION; HYPERTENSION; ASSOCIATION; MIDLIFE; HEALTH;
D O I：
10.1159/000362265
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Background: Midlife metabolic syndrome (MetS) may impact cognitive health as a construct independently of hypertension, hyperlipidemia and other components. Methods: 10,866 participants aged 45-64 years at baseline were assessed for MetS and completed cognitive testing at two later time points (3 and 9 years from the baseline visit). Results: MetS is associated with increased odds of low cognitive performance in the domains of executive function and word fluency, but not with 6-year cognitive decline. Individual MetS components explained this association (hypertension, diabetes, low HDL, elevated triglycerides and increased waist circumference). Conclusions: A focus on the individual risk factors as opposed to MetS during midlife is important to reduce the incidence of cognitive impairment in later life. (C) 2014 S. Karger AG, Basel
引用
收藏
页码：337 / 346
页数：10
相关论文
共 50 条
  • [21] Orthostatic Hypotension and Cognitive Function: The Atherosclerosis Risk in Communities (ARIC) Study
    Gottesman, Rebecca F.
    Rose, Kathryn M.
    Couper, David J.
    Eigenbrodt, Marsha L.
    Mosley, Thomas H.
    Sharrett, A. Richey
    CIRCULATION, 2009, 119 (10) : E334 - E334
  • [22] Milk Intake at Midlife and Cognitive Decline over 20 Years. The Atherosclerosis Risk in Communities (ARIC) Study
    Petruski-Ivleva, Natalia
    Kucharska-Newton, Anna
    Palta, Priya
    Couper, David
    Meyer, Katie
    Graff, Misa
    Haring, Bernhard
    Sharrett, Richey
    Heiss, Gerardo
    NUTRIENTS, 2017, 9 (10):
  • [23] Nutrition and Cognitive Decline Over 21-years: Results from the Atherosclerosis Risk in Communities Study (ARIC)
    Dearborn, Jennifer L.
    Wu, Aozhou
    Steffen, Lyn M.
    Knopman, David S.
    Mosley, Thomas H.
    Gottesman, Rebecca F.
    STROKE, 2017, 48
  • [24] The Association of Longitudinal Changes in Metabolic Syndrome With Incident Heart Failure: The Atherosclerosis Risk in Communities (ARIC) Study
    Adesiyun, Tolulope A.
    Kwak, Lucia
    Sharma, Kavita
    Nambi, Vijay
    Michos, Erin D.
    Neeland, Ian
    Blumenthal, Roger S.
    Ballantyne, Christie M.
    Selvin, Elizabeth
    Coresh, Josef
    Ndumele, Chiadi E.
    CIRCULATION, 2018, 137
  • [25] Metabolic syndrome and incidence of atrial fibrillation among blacks and whites in the Atherosclerosis Risk in Communities (ARIC) Study
    Chamberlain, Alanna M.
    Agarwal, Sunil K.
    Ambrose, Marietta
    Folsom, Aaron R.
    Soliman, Elsayed Z.
    Alonso, Alvaro
    AMERICAN HEART JOURNAL, 2010, 159 (05) : 850 - 856
  • [26] Individual and Neighborhood Socioeconomic Status Characteristics and Prevalence of Metabolic Syndrome: The Atherosclerosis Risk in Communities (ARIC) Study
    Chichlowska, Kristal L.
    Rose, Kathryn M.
    Diez-Roux, Ana V.
    Golden, Sherita H.
    McNeill, Annie M.
    Heiss, Gerardo
    PSYCHOSOMATIC MEDICINE, 2008, 70 (09): : 986 - 992
  • [27] Adipokines and Transitions in Metabolic Risk Over Time: The Atherosclerosis Risk in Communities (ARIC) Study
    Ozkan, Bige
    Zhang, Sui
    Tcheugui, Justin B. Echouffo
    Florido, Roberta
    Nambi, Vijay
    Michos, Erin D.
    Abushamat, Layla
    Matsushita, Kuni
    Gerstenblith, Gary
    Blumenthal, Roger
    Hoogeveen, Ron C.
    Ballantyne, Christie M.
    Coresh, Josef
    Selvin, Elizabeth
    Ndumele, Chiadi E.
    CIRCULATION, 2022, 146
  • [28] Hypokalemia in the atherosclerosis risk in communities (ARIC) study
    Andrew, ME
    Brown, CA
    Schreiner, PJ
    Young, DB
    Wofford, MR
    Wyatt, SB
    Jones, DW
    CIRCULATION, 1998, 98 (17) : 861 - 861
  • [29] Estrogen replacement therapy and cognitive functioning in the atherosclerosis risk in communities (ARIC) study
    Szklo, M
    Cerhan, J
    DiezRoux, AV
    Chambless, L
    Cooper, L
    Folsom, AR
    Fried, LP
    Knopman, D
    Nieto, FJ
    AMERICAN JOURNAL OF EPIDEMIOLOGY, 1996, 144 (11) : 1048 - 1057
  • [30] Associations between occupation, retirement age and 20-year cognitive decline: The Atherosclerosis Risk in Communities (ARIC) Study
    Liu, Albert C.
    Patel, Mehul D.
    Gross, Alden L.
    Mosley, Thomas H.
    Schneider, Andrea L. C.
    Kucharska-Newton, Anna M.
    Sharrett, A. Richey
    Gottesman, Rebecca F.
    Konto, Silvia
    INTERNATIONAL PSYCHOGERIATRICS, 2024, 36 : 143 - 143
12345