Adhesion molecules and the extracellular matrix as drug targets for glioma

被引：27
|
作者：
Shimizu, Toshihiko [1 ]
Kurozumi, Kazuhiko [1 ]
Ishida, Joji [1 ]
Ichikawa, Tomotsugu [1 ]
Date, Isao [1 ]
机构：
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan
来源：
BRAIN TUMOR PATHOLOGY | 2016年 / 33卷 / 02期
关键词：
Malignant glioma; Adhesion molecules; Extracellular matrix; Angiogenesis; Invasion; BRAIN-SPECIFIC ANGIOGENESIS; COLLAGEN XVI EXPRESSION; RANDOMIZED PHASE-II; CELL-ADHESION; INTEGRIN ALPHA(V)BETA(3); MALIGNANT GLIOMAS; IN-VIVO; ENDOTHELIAL-CELLS; PROTEIN CCN1; GENE-THERAPY;
D O I：
10.1007/s10014-016-0261-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The formation of tumor vasculature and cell invasion along white matter tracts have pivotal roles in the development and progression of glioma. A better understanding of the mechanisms of angiogenesis and invasion in glioma will aid the development of novel therapeutic strategies. The processes of angiogenesis and invasion cause the production of an array of adhesion molecules and extracellular matrix (ECM) components. This review focuses on the role of adhesion molecules and the ECM in malignant glioma. The results of clinical trials using drugs targeted against adhesion molecules and the ECM for glioma are also discussed.
引用
收藏
页码：97 / 106
页数：10
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