Chiral specificity of novel platinum complexes in their cross-membrane transport and DNA molecular recognition

被引：0
|
作者：
Yang, M [1 ]
Hu, QY [1 ]
Zhang, LR [1 ]
Zhu, SM [1 ]
Zou, J [1 ]
Li, RC [1 ]
Wang, K [1 ]
机构：
[1] Beijing Med Univ, Natl Res Labs Nat & Biomimet Drugs, Beijing 100083, Peoples R China
来源：
SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE | 1997年 / 50卷 / 04期
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of new chiral Pt-complexes has been designed and synthesised. The effects of the chiral features and stereochemistry of newly-synthesised complexes on their anticancer activity, cross-membrane transport and DNA molecular recognition have been studied. The effects of chiral specificity on the cross-membrane transport of Pt-complexes were monitored by measuring the platinum concentration in the cytosol as a function of time. Specific interaction of DNA with three different chiral complexes were investigated by biomicrocalorimetric and CD techniques, and DNA T-m measurements. R,R-Pt was found to be the most active in its cross-membrane transport and its interaction with DNA, which agreed with results in the anticancer tests in vitro. Direct evidence for molecular mechanism of DNA specificity of chiral Pt-complexes was found by HPLC elucidated by molecular modelling studies.
引用
收藏
页码：227 / 231
页数：5
相关论文
共 50 条
  • [41] A novel fluorescent reagent for recognition of triplex DNA with high specificity and selectivity
    Chen, Zongbao
    Zhang, Huimi
    Ma, Xiaoming
    Lin, Zhenyu
    Zhang, Lan
    Chen, Guonan
    ANALYST, 2015, 140 (22) : 7742 - 7747
  • [42] Molecular recognition and membrane transport with mixed-ligand borates
    Riggs, JA
    Litchfield, RK
    Smith, BD
    JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (03): : 1148 - 1150
  • [43] Chiral rhodium(III)-azobenzene complexes as photoswitchable DNA molecular locks
    Lin, Mingwei
    Zou, Shanshan
    Li, Tingzhen
    Karges, Johannes
    Chen, Yu
    Zhao, Yukun
    Ji, Liangnian
    Chao, Hui
    CHEMICAL COMMUNICATIONS, 2022, 58 (27) : 4324 - 4327
  • [44] DNA Binding and Anticancer Activity of Novel Cyclometalated Platinum (II) Complexes
    Mohammadi, Roghayeh
    Yousefi, Reza
    Aseman, Marzieh Dadkhah
    Nabavizadeh, S. Masoud
    Rashidi, Mehdi
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2015, 15 (01) : 107 - 114
  • [45] Novel DNA and PNA analogs: Selectivity in DNA molecular recognition.
    Ganesh, KN
    Kumar, VA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 218 : U205 - U205
  • [46] Synthesis and biological evaluation of novel dinuclear platinum(II) complexes derived from a novel chiral ligand
    Zhang, Zhuxin
    Li, Chunli
    Sun, Xiaojun
    Gao, Chuanzhu
    Yu, Congtao
    Liu, Qinghua
    Bai, Linkui
    Qian, Yunxu
    Yang, Bo
    Dong, Peng
    Zhang, Yingjie
    INORGANICA CHIMICA ACTA, 2017, 455 : 166 - 172
  • [47] Enantioselective quenching of luminescence: Molecular recognition of chiral lanthanide complexes by biomolecules in solution
    Meskers, SCJ
    Dekkers, HPJM
    JOURNAL OF PHYSICAL CHEMISTRY A, 2001, 105 (19): : 4589 - 4599
  • [48] CD spectroscopic study on the molecular recognition of chiral salen-metal complexes
    Liu, T
    Ruan, WJ
    Nan, J
    Zhu, ZA
    CHINESE JOURNAL OF CHEMISTRY, 2003, 21 (07) : 751 - 755
  • [49] Accounting for Specificity and Cross-Reactivity in T Cell Receptor Molecular Recognition
    Baker, Brian M.
    BIOPHYSICAL JOURNAL, 2018, 114 (03) : 219A - 219A
  • [50] Study on the molecular recognition of new chiral salen Zn(II) binuclear complexes
    Hua, H
    Yuan, WF
    Ruan, WJ
    Zhao, XJ
    Hu, GH
    Zhu, ZA
    ACTA PHYSICO-CHIMICA SINICA, 2004, 20 (05) : 529 - 534
12345