The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients

被引：10

作者：

Friis, Anna M. C. ^{[1
]}

Gyllensten, Katarina ^{[2
]}

Aleman, Anna ^{[1
]}

Ernberg, Ingemar ^{[1
]}

Akerlund, Borje ^{[3
]}

机构：

[1] Karolinska Inst, Ctr Microbiol & Tumor Biol, SE-17165 Stockholm, Sweden

[2] Karolinska Inst, Gay Mens Hlth Clin, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden

[3] Karolinska Univ Hosp, Dept Infect Dis, SE-14186 Stockholm, Sweden

来源：

VIRUSES-BASEL | 2010年 / 2卷 / 04期

基金：

英国医学研究理事会;

关键词：

Epstein-Barr virus; HIV-1; antiretroviral treatment; host virus relationship; HUMAN-IMMUNODEFICIENCY-VIRUS; NON-HODGKINS-LYMPHOMA; POLYMERASE-CHAIN-REACTION; LYMPHOPROLIFERATIVE DISEASE; RISK-FACTORS; DNA; PATHOGENESIS; RESTORATION; THERAPY; TYPE-1;

D O I：

10.3390/v2040867

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We evaluated the effect of combination anti-retroviral treatment (cART) on the host control of EBV infection in moderately immunosuppressed HIV-1 patients. Twenty HIV-1 infected individuals were followed for five years with repeated measurements of EBV DNA load in peripheral blood lymphocytes in relation to HIV-RNA titers and CD4+ cell counts. Individuals with optimal response, i.e. durable non-detectable HIV-RNA, showed a decline of EBV load to the level of healthy controls. Individuals with non-optimal HIV-1 control did not restore their EBV control. Long-lasting suppression of HIV-replication after early initiation of cART is a prerequisite for re-establishing the immune control of EBV.

引用

页码：867 / 879

页数：13

共 40 条

[1] SIMPLE, SENSITIVE, AND SPECIFIC DETECTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN CLINICAL SPECIMENS BY POLYMERASE CHAIN-REACTION WITH NESTED PRIMERS [J].

ALBERT, J ;

FENYO, EM .

JOURNAL OF CLINICAL MICROBIOLOGY, 1990, 28 (07) :1560-1564

[2] Epstein-Barr virus-DNA load monitoring late after lung transplantation: A surrogate marker of the degree of immunosuppression and a safe guide to reduce immunosuppression [J].

Bakker, Nicolaas A. ;

Verschuuren, Erik A. M. ;

Erasmus, Michiel E. ;

Hepkema, Bouke G. ;

Veeger, Nicj. G. M. ;

Kallenberg, Cees G. M. ;

van der Bij, Wim .

TRANSPLANTATION, 2007, 83 (04) :433-438

[3] Evolving epidemiology of malignancies in HIV [J].

Bonnet, Fabrice ;

Chene, Genevieve .

CURRENT OPINION IN ONCOLOGY, 2008, 20 (05) :534-540

[4] CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK [J].

Bower, Mark ;

Fisher, Martin ;

Hill, Teresa ;

Reeves, Iain ;

Walsh, John ;

Orkin, Chloe ;

Phillips, Andrew N. ;

Bansi, Loveleen ;

Gilson, Richard ;

Easterbrook, Philippa ;

Johnson, Margaret ;

Gazzard, Brian ;

Leen, Clifford ;

Pillay, Deenan ;

Schwenk, Achim ;

Anderson, Jane ;

Porter, Kholoud ;

Gompels, Mark ;

Sabin, Caroline A. .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 (06) :875-880

[5] HIGH EXPRESSION OF LATENT MEMBRANE-PROTEIN-1 OF EPSTEIN-BARR-VIRUS AND BCL-2 ONCOPROTEIN IN ACQUIRED IMMUNODEFICIENCY SYNDROME-RELATED PRIMARY BRAIN LYMPHOMAS [J].

CAMILLERIBROET, S ;

DAVI, F ;

FEUILLARD, J ;

BOURGEOIS, C ;

SEILHEAN, D ;

HAUW, JJ ;

RAPHAEL, M .

BLOOD, 1995, 86 (02) :432-435

[6] Clinical indicators of immune restoration following highly active antiretroviral therapy [J].

Cooney, EL .

CLINICAL INFECTIOUS DISEASES, 2002, 34 (02) :224-233

[7]

Ehlin-Henriksson B, 1999, INT J CANCER, V83, P50, DOI 10.1002/(SICI)1097-0215(19990924)83:1<50::AID-IJC10>3.0.CO

[8]

2-1

[9]

ENGELS EA, J ACQUIR IM IN PRESS

[10]

ERNBERG I, 1986, PROG ALLERGY, V37, P301

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