t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia

被引：27
作者：
Vizmanos, JL
Larráyoz, MJ
Lahortiga, I
Floristán, F
Alvarez, C
Odero, MD
Novo, FJ
Calasanz, MJ
机构：
[1] Univ Navarra, Dept Genet, Sch Sci, E-31080 Pamplona, Spain
[2] Hosp Cruces, Hematol Serv, Serv Vasco Salud Osakidetza, Barcelona, Spain
来源：
GENES CHROMOSOMES & CANCER | 2003年 / 36卷 / 04期
关键词：
D O I：
10.1002/gcc.10174
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(I 0; 1 6)(q22;p 13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码：402 / 405
页数：4
相关论文
共 31 条
[1]  
Billio Atto, 2002, Haematologica, V87, pECR15
[2]  
Blobel GA, 2002, J LEUKOCYTE BIOL, V71, P545
[3]   The translocation t(8;l6)(p11, p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB binding protein [J].
Borrow, J ;
Stanton, VP ;
Andresen, JM ;
Becher, R ;
Behm, FG ;
Chaganti, RSK ;
Civin, CI ;
Disteche, C ;
Dube, I ;
Frischauf, AM ;
Horsman, D ;
Mitelman, F ;
Volinia, S ;
Watmore, AE ;
Housman, DE .
NATURE GENETICS, 1996, 14 (01) :33-41
[4]   Transcriptional regulation of erythropoiesis: an affair involving multiple partners [J].
Cantor, AB ;
Orkin, SH .
ONCOGENE, 2002, 21 (21) :3368-3376
[5]   Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13) [J].
Carapeti, M ;
Aguiar, RCT ;
Watmore, AE ;
Goldman, JM ;
Cross, NCP .
CANCER GENETICS AND CYTOGENETICS, 1999, 113 (01) :70-72
[6]   A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia [J].
Carapeti, M ;
Aguiar, RCT ;
Goldman, JM ;
Cross, NCP .
BLOOD, 1998, 91 (09) :3127-3133
[7]  
Chaffanet M, 1999, GENE CHROMOSOME CANC, V26, P161, DOI 10.1002/(SICI)1098-2264(199910)26:2<161::AID-GCC8>3.0.CO
[8]  
2-6
[9]  
Chaffanet M, 2000, GENE CHROMOSOME CANC, V28, P138, DOI 10.1002/(SICI)1098-2264(200006)28:2<138::AID-GCC2>3.0.CO
[10]  
2-2
1234