Isolation of secondary metabolites from Geranium molle L. with anticancer potential

被引：5

作者：

Graca, V. C. ^{[1
,2
,3
]}

Calhelha, Ricardo C. ^{[3
]}

Nunes, Fernando M. ^{[1
]}

Berthet, Jerome ^{[4
]}

Ferreira, Isabel C. F. R. ^{[3
]}

Santos, P. F. ^{[1
]}

机构：

[1] Univ Tras Os Montes & Alto Douro, Ctr Quim Vila Real CQ VR, P-5001801 Vila Real, Portugal

[2] Univ Tras Os Montes & Alto Douro, Ctr Res & Technol Agroenvironm & Biol Sci CITAB V, P-5001801 Vila Real, Portugal

[3] Inst Politecn Braganca, Ctr Invest Montanha CIMO, Campus Santa Apolonia, P-5300253 Braganca, Portugal

[4] Univ Lille, LASIR Lab Spectrochim Infra Rouge & Raman, CNRS, UMR 8516, F-59000 Lille, France

来源：

INDUSTRIAL CROPS AND PRODUCTS | 2019年 / 142卷

关键词：

Geranium molle L; Cytotoxic activity; Phenolic compounds; Secondary metabolites; ISOORIENTIN INDUCES APOPTOSIS; PHENOLIC-COMPOUNDS; CHEMICAL-CHARACTERIZATION; CANCER; ELLAGITANNINS; BIOACTIVITY; PATHWAYS; PI3K/AKT; EXTRACT; CELLS;

D O I：

10.1016/j.indcrop.2019.111859

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

Two flavone glycosides, apigenin-6-C-glucoside (1) and lutelin-6-C-glucoside (2), and an anomeric mixture of 2,3-dygalloyl-4,6-HHDP-D-glucose (3a/3b) were isolated for the first time from Geranium molle L., a medicinal plant used in the folk medicine of northeast of Portugal for the treatment of a variety of ailments, including cancer. The cytotoxic activity of the isolated compounds was assessed against several human tumour cell lines and non-tumour porcine liver primary cells. The anomeric mixture of ellagitannins 3a/3b, with the two anomers showing considerably different hydrophobicities, was found to be significantly cytotoxic against cancer cells, with only moderate hepatotoxicity.

引用

页数：5

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