Synthesis, Structure, and Antibacterial Evaluation of New N-Substituted-3-Amino-5-oxo-4-phenyl-2,5-dihydro-1H-pyrazole-1-carbothioamides

被引：9

作者：

Pitucha, Monika ^{[1
]}

Mazur, Liliana ^{[2
]}

Kosikowska, Urszula ^{[3
]}

Pachuta-Stec, Anna

Malm, Anna ^{[1
,3
]}

Popiolek, Lukasz ^{[1
]}

Rzaczynska, Zofia ^{[2
]}

机构：

[1] Med Univ, Fac Pharm, Dept Organ Chem, PL-20081 Lublin, Poland

[2] Maria Curie Slodowska Univ, Dept Gen & Coordinat Chem, PL-20031 Lublin, Poland

[3] Med Univ, Dept Pharmaceut Microbiol, PL-20093 Lublin, Poland

来源：

HETEROATOM CHEMISTRY | 2010年 / 21卷 / 04期

关键词：

CRYSTAL-STRUCTURES; SUSCEPTIBILITY; DERIVATIVES; ANALOGS; DESIGN;

D O I：

10.1002/hc.20598

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel N-substituted-3-amino-5-oxo-4-phenyl-2,5-dihydro-1H-pyrazole-1-carbothioamide derivatives were synthesized by means of two methods. First is the cyclization reaction of I(cyanophenyl)acetyl-4-substituted thiosemicarbazide, and the second one is reaction of cyanophenyl acetic acid hydrazide with isothiocyanate. Structures of new compounds were confirmed by elemental analysis, H NMR, and X-ray diffraction analysis. Biological evaluation showed that some of them possess promising antibacterial activities. (C) 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:215-221, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20598

引用

页码：215 / 221

页数：7

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