Control of Streptococcus pneumoniae serotype 5 epidemic of severe pneumonia among young army recruits by mass antibiotic treatment and vaccination

被引：29

作者：

Balicer, Ran D. ^{[2
]}

Zarka, Salman ^{[3
]}

Levine, Hagai ^{[2
]}

Klement, Eyal ^{[4
]}

Sela, Tamar

Porat, Nurith ^{[1
,2
]}

Ash, Nachman

Dagan, Ron ^{[1
,2
]}

机构：

[1] Soroka Univ, Med Ctr, Pediat Infect Dis Unit, IL-84101 Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel

[3] Univ Haifa, Sch Publ Hlth, IL-31999 Haifa, Israel

[4] Hebrew Univ Jerusalem, Koret Sch Vet Med, Smith Fac Agr Food & Environm, IL-76100 Rehovot, Israel

来源：

VACCINE | 2010年 / 28卷 / 34期

关键词：

Pneumonia; Streptococcus pneumoniae; Outbreak; Vaccine; Young adults; Carriage; PNEUMOCOCCAL PNEUMONIA; NASOPHARYNGEAL CARRIAGE; CAPSULAR POLYSACCHARIDES; MILITARY PERSONNEL; INVASIVE DISEASE; OUTBREAK; INFECTION; PREVALENCE; COMMUNITY; IDENTIFICATION;

D O I：

10.1016/j.vaccine.2010.06.031

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During an outbreak of severe pneumonia among new army recruits, an epidemiological investigation combined with repeated nasopharyngeal/oropharyngeal cultures from sick and healthy contacts subjects was conducted. Fifteen pneumonia cases and 19 influenza-like illness cases occurred among 596 recruits over a 4-week period in December 2005. Pneumonia attack rates reached up to 5.5%. A single pneumococcus serotype 5 clone was isolated from blood or sputum cultures in 4 patients and 30/124 (24.1%) contacts. Immunization with 23-valent polysaccharide vaccine supplemented with a 2-dose azithromycin mass treatment rapidly terminated the outbreak. Carriage rates dropped to <1%, 24 and 45 days after intervention. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5591 / 5596

页数：6

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