Immune responses to AAV capsid: Are mice not humans after all?

被引:44
作者
Herzog, Roland W. [1 ]
机构
[1] Univ Florida, Div Mol & Cellular Therapy, Gainesville, FL 32610 USA
关键词
D O I
10.1038/sj.mt.6300123
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
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页码:649 / 650
页数:2
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共 16 条
  • [1] Determination of specific CD4 and CD8 T cell epitopes after AAV2-and AAV8-hF.IX gene therapy
    Chen, J
    Wu, Q
    Yang, P
    Hsu, HC
    Mountz, JD
    [J]. MOLECULAR THERAPY, 2006, 13 (02) : 260 - 269
  • [2] Recombinant adeno-associated virus for muscle directed gene therapy
    Fisher, KJ
    Jooss, K
    Alston, J
    Yang, YP
    Haecker, SE
    High, K
    Pathak, R
    Raper, SE
    Wilson, JM
    [J]. NATURE MEDICINE, 1997, 3 (03) : 306 - 312
  • [3] Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector
    Herzog, RW
    Yang, EY
    Couto, LB
    Hagstrom, JN
    Elwell, D
    Fields, PA
    Burton, M
    Bellinger, DA
    Read, MS
    Brinkhous, KM
    Podsakoff, GM
    Nichols, TC
    Kurtzman, GJ
    High, KA
    [J]. NATURE MEDICINE, 1999, 5 (01) : 56 - 63
  • [4] Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein
    Kessler, PD
    Podsakoff, GM
    Chen, XJ
    McQuiston, SA
    Colosi, PC
    Matelis, LA
    Kurtzman, GJ
    Byrne, BJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) : 14082 - 14087
  • [5] Pre-existing AAV capsid-specific CD8+ T cells are unable to eliminate AAV-transduced hepatocytes
    Li, Hua
    Murphy, Samuel L.
    Giles-Davis, Wynetta
    Edmonson, Shyrie
    Xiang, Zhiquan
    Li, Yan
    Lasaro, Marcio O.
    High, Katherine A.
    Ertl, Hildegund C. J.
    [J]. MOLECULAR THERAPY, 2007, 15 (04) : 792 - 800
  • [6] AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B
    Manno, CS
    Chew, AJ
    Hutchison, S
    Larson, PJ
    Herzog, RW
    Arruda, VP
    Tai, SJ
    Ragni, MV
    Thompson, A
    Ozelo, M
    Couto, LB
    Leonard, DGB
    Johnson, FA
    McClelland, A
    Scallan, C
    Skarsgard, E
    Flake, AW
    Kay, MA
    High, KA
    Glader, B
    [J]. BLOOD, 2003, 101 (08) : 2963 - 2972
  • [7] Successful transduction of liver in hemophilia by AAV-factor IX and limitations imposed by the host immune response
    Manno, CS
    Arruda, VR
    Pierce, GF
    Glader, B
    Ragni, M
    Rasko, J
    Ozelo, MC
    Hoots, K
    Blatt, P
    Konkle, B
    Dake, M
    Kaye, R
    Razavi, M
    Zajko, A
    Zehnder, J
    Nakai, H
    Chew, A
    Leonard, D
    Wright, JF
    Lessard, RR
    Sommer, JM
    Tigges, M
    Sabatino, D
    Luk, A
    Jiang, HY
    Mingozzi, F
    Couto, L
    Ertl, HC
    High, KA
    Kay, MA
    [J]. NATURE MEDICINE, 2006, 12 (03) : 342 - 347
  • [8] T Cell Responses to AAV Vector Capsid in Normal Donors and Subjects Who Have Undergone Liver-Directed AAV-Mediated Gene Transfer
    Maus, Marcela V.
    Mingozzi, Federico
    Sabatino, Denise E.
    Hui, Daniel
    Ragni, Margaret V.
    High, Katherine A.
    [J]. MOLECULAR THERAPY, 2006, 13 : S282 - S282
  • [9] Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer
    Mingozzi, F
    Liu, YL
    Dobrzynski, E
    Kaufhold, A
    Liu, JH
    Wang, YQ
    Arruda, VR
    High, KA
    Herzog, RW
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (09) : 1347 - 1356
  • [10] Mingozzi F, 2006, BLOOD, V108, p138A