Oxidation versus aggregation - how do SOD1 mutants cause ALS?

被引：84

作者：

Cleveland, DW

Liu, J

机构：

[1] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 12期

关键词：

D O I：

10.1038/82122

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multiple models have been proposed for the mechanism by which mutant superoxide dismutase 1 induces motor neuron death and amyotrophic lateral sclerosis. A combination of cell biology and genetics may soon lead to an answer.

引用

页码：1320 / 1321

页数：2

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