Sensing and signaling during infection in Drosophila

被引：140

作者：

Royet, J ^{[1
]}

Reichhart, JM ^{[1
]}

Hoffmann, JA ^{[1
]}

机构：

[1] CNRS, Inst Biol Mol & Cellulaire, UPR 9022, F-67084 Strasbourg, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2005年 / 17卷 / 01期

关键词：

D O I：

10.1016/j.coi.2004.12.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most of the progress in dissecting the Drosophila antimicrobial response over the past decade has centered around intracellular signaling pathways in immune response tissues and expression of genes encoding antimicrobial peptide genes. The past few years, however, have witnessed significant advances in our understanding of the recognition of microbial invaders and subsequent activation of signaling cascades. In particular, the roles of peptidoglycan recognition proteins, which have known homologues in mammals, have been recognized and examined at the structural and functional levels.

引用

页码：11 / 17

页数：7

共 42 条

[1] Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury [J].

Agaisse, H ;

Petersen, UM ;

Boutros, M ;

Mathey-Prevot, B ;

Perrimon, N .

DEVELOPMENTAL CELL, 2003, 5 (03) :441-450

[2] The Drosophila atypical protein kinase C-Ref(2)P complex constitutes a conserved module for signaling in the toll pathway [J].

Avila, A ;

Silverman, N ;

Diaz-Meco, MT ;

Moscat, J .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (24) :8787-8795

[3] Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria [J].

Bischoff, V ;

Vignal, C ;

Boneca, IG ;

Michel, T ;

Hoffmann, JA ;

Royet, J .

NATURE IMMUNOLOGY, 2004, 5 (11) :1175-1180

[4] Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae [J].

Blandin, S ;

Shiao, SH ;

Moita, LF ;

Janse, CJ ;

Waters, AP ;

Kafatos, FC ;

Levashina, EA .

CELL, 2004, 116 (05) :661-670

[5] Sequential activation of signaling pathways during innate immune responses in Drosophila [J].

Boutros, M ;

Agaisse, H ;

Perrimon, N .

DEVELOPMENTAL CELL, 2002, 3 (05) :711-722

[6] A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity [J].

Chang, CI ;

Pili-Floury, S ;

Hervé, M ;

Parquet, C ;

Chelliah, Y ;

Lemaitre, B ;

Mengin-Lecreulx, D ;

Deisenhofer, J .

PLOS BIOLOGY, 2004, 2 (09) :1293-1302

[7] Krapfen/dMyd88 is required for the establishment of dorsoventral pattern in the Drosophila embryo [J].

Charatsi, I ;

Luschnig, S ;

Bartoszewski, S ;

Nüsslein-Volhard, C ;

Moussian, B .

MECHANISMS OF DEVELOPMENT, 2003, 120 (02) :219-226

[8] Requirement for a peptidoglycan recognition protein (PGRP) in relish activation and antibacterial immune responses in Drosophila [J].

Choe, KM ;

Werner, T ;

Stöven, S ;

Hultmark, D ;

Anderson, KV .

SCIENCE, 2002, 296 (5566) :359-362

[9] Peptidoglycan recognition proteins (PGRPs) [J].

Dziarski, R .

MOLECULAR IMMUNOLOGY, 2004, 40 (12) :877-886

[10] Dual activation of the Drosophila Toll pathway by two pattern recognition receptors [J].

Gobert, V ;

Gottar, M ;

Matskevich, AA ;

Rutschmann, S ;

Royet, J ;

Belvin, M ;

Hoffmann, JA ;

Ferrandon, D .

SCIENCE, 2003, 302 (5653) :2126-2130

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