Anticancer effects of the microbiome and its products

被引:382
作者
Zitvogel, Laurence [1 ,2 ,3 ,4 ]
Daillere, Romain [1 ,2 ,3 ]
Roberti, Maria Paula [1 ,2 ,3 ]
Routy, Bertrand [1 ,2 ,3 ]
Kroemer, Guido [4 ,5 ,6 ,7 ,8 ,9 ,10 ]
机构
[1] Inst Cancerol Gustave Roussy Canc Campus GRCC, 114 Rue Edouard Vaillant, F-94805 Villejuif, France
[2] GRCC, INSERM, U1015, F-94805 Villejuif, France
[3] Univ Paris Saclay, F-94270 Le Kremlin Bicetre, France
[4] GRCC, Ctr Clin Invest CIC1428, F-94805 Villejuif, France
[5] Ctr Rech Cordeliers, INSERM, U1138, Equipe Labelisee Ligue Natl Canc 11, F-75006 Paris, France
[6] Univ Paris 05, Sorbonne Paris Cite, F-75006 Paris, France
[7] Univ Paris 06, F-75006 Paris, France
[8] Hop Europeen Georges Pompidou, Pole Biol, F-75015 Paris, France
[9] GRCC, Metabol & Cell Biol Platforms, F-94805 Villejuif, France
[10] Karolinska Inst, Karolinska Univ Hosp, Dept Womens & Childrens Hlth, S-17176 Stockholm, Sweden
基金
欧洲研究理事会; 欧盟地平线“2020”;
关键词
BACILLUS-CALMETTE-GUERIN; CERVICAL INTRAEPITHELIAL NEOPLASIA; CHAIN FATTY-ACIDS; PHASE-I TRIAL; LACTOBACILLUS-CASEI; GUT MICROBIOTA; INTESTINAL MICROBIOTA; COLORECTAL-CANCER; MYCOBACTERIUM-BOVIS; FECAL MICROBIOTA;
D O I
10.1038/nrmicro.2017.44
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The human gut microbiome modulates many host processes, including metabolism, inflammation, and immune and cellular responses. It is becoming increasingly apparent that the microbiome can also influence the development of cancer. In preclinical models, the host response to cancer treatment has been improved by modulating the gut microbiome; this is known to have an altered composition in many diseases, including cancer. In addition, cancer treatment with microbial agents or their products has the potential to shrink tumours. However, the microbiome could also negatively influence cancer prognosis through the production of potentially oncogenic toxins and metabolites by bacteria. Thus, future antineoplastic treatments could combine the modulation of the microbiome and its products with immunotherapeutics and more conventional approaches that directly target malignant cells.
引用
收藏
页码:465 / 478
页数:14
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