In vitro spontaneous and UVB-induced lymphocyte apoptosis are not specific to SLE.

被引：7

作者：

Abe, M ^{[1
]}

Ishikawa, O ^{[1
]}

Miyachi, Y ^{[1
]}

Kanai, Y ^{[1
]}

机构：

[1] Gunma Univ, Sch Med, Dept Dermatol, Gunma 371, Japan

来源：

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE | 1997年 / 13卷 / 5-6期

关键词：

lymphocyte apoptosis; ultraviolet light-B irradiation; systemic lupus erythematosus;

D O I：

10.1111/j.1600-0781.1997.tb00232.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We studied in vitro spontaneous and ultraviolet light (UV)-induced lymphocyte apoptosis in patients with systemic lupus erythematosus (SLE, n=11), cutaneous lupus erythematosus (CLE, n=8), and other collagen diseases(n=6), as well as normal individuals(n=6), Apoptosis was confirmed by the presence of a 180 bp DNA ladder on gel electrophoresis. WE-induced apoptosis was observed in 4 of 11 patients with SLE (36.3%), 3 of 8 patients with CLE (37.5%) and 2 of 6 patients (33.3%) with other collagen diseases. There was no clinical correlation between clinical photosensitivity and UV-induced apoptosis. Similarly, spontaneous apoptosis was also found in lymphocytes from patients with diseases other than SLE. No apoptosis was found in normal subjects with or without UVE irradiation (25 mJ/cm(2)). These data suggest that UV-induced lymphocyte apoptosis may not be specific to SLE but may be common in collagen diseases.

引用

页码：204 / 207

页数：4

共 24 条

[1] ABERRANT TRANSCRIPTION CAUSED BY THE INSERTION OF AN EARLY TRANSPOSABLE ELEMENT IN AN INTRON OF THE FAS ANTIGEN GENE OF LPR MICE [J].