Enantioselective addition of phenyl and alkyl acetylenes to imines catalyzed by chiral Cu(I) complexes

被引：69

作者：

Benaglia, M ^{[1
]}

Negri, D ^{[1
]}

Dell'Anna, G ^{[1
]}

机构：

[1] Politecn Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 47期

关键词：

propargyl amines; chiral bis-imines; acetylenes addition; chiral ligands; asymmetric catalysis;

D O I：

10.1016/j.tetlet.2004.09.138

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective addition of phenyl acetylene and alkyl acetylenes to imines, catalyzed by chiral bis-imines-Cu(1) complexes was studied. A very simple experimental procedure allowed to obtain at room temperature optically active propargyl amines in very good yields and enantioselectivity up to 81%. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8705 / 8708

页数：4

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