Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects

被引:152
作者
Bravo, Denisse [1 ]
Hoare, Anilei [1 ]
Soto, Cristopher [1 ]
Valenzuela, Manuel A. [2 ]
Quest, Andrew F. G. [3 ]
机构
[1] Univ Chile, Fac Dent, Pathol & Oral Med Dept, Oral Microbiol Lab, Santiago 8380492, Chile
[2] Univ Cent Chile, Fac Hlth Sci, Adv Ctr Chron Dis, Inst Hlth Related Res & Innovat, Santiago 8380447, Chile
[3] Univ Chile, Fac Med, Biomed Sci Inst, Adv Ctr Chron Dis,Ctr Studies Exercise Metab & Ca, Ave Independencia 1027, Santiago 8380447, Chile
关键词
Helicobacter pylori; Co-evolution; Extra-gastric diseases; Inflammation; Microbiome; GAMMA-GLUTAMYL-TRANSPEPTIDASE; IMMUNE EVASION STRATEGIES; TYPE-2; DIABETES-MELLITUS; IRON-DEFICIENCY ANEMIA; INSULIN-RESISTANCE; BACTERIAL-FLORA; PERIODONTAL-DISEASE; MULTIPLE-SCLEROSIS; CHOLESTEROL GLUCOSYLATION; MYOCARDIAL-INFARCTION;
D O I
10.3748/wjg.v24.i28.3071
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Helicobacter pylori (H. pylori) is present in roughly 50% of the human population worldwide and infection levels reach over 70% in developing countries. The infection has classically been associated with different gastro-intestinal diseases, but also with extra gastric diseases. Despite such associations, the bacterium frequently persists in the human host without inducing disease, and it has been suggested that H. pylori may also play a beneficial role in health. To understand how H. pylori can produce such diverse effects in the human host, several studies have focused on understanding the local and systemic effects triggered by this bacterium. One of the main mechanisms by which H. pylori is thought to damage the host is by inducing local and systemic inflammation. However, more recently, studies are beginning to focus on the effects of H. pylori and its metabolism on the gastric and intestinal microbiome. The objective of this review is to discuss how H. pylori has co-evolved with humans, how H. pylori presence is associated with positive and negative effects in human health and how inflammation and/or changes in the microbiome are associated with the observed outcomes.
引用
收藏
页码:3071 / 3089
页数:19
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